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EC number: 421-320-0 | CAS number: 118289-55-7 CP-89,575
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 18, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- A representative sample of the process intermediate CP-89,575 was evaluated in rats for potential toxicity following oral exposure . The test conditions used to assess toxicity following oral administration were designed to incorporate those described by the United States Department of Transportation (DOT) under CFR Title 49, Section 173.343. These studies were also compatible with classification of the compound by the EEC according to the guidelines presented in the Official Journal of the European Communities (No. C33/18; dated 2/13/90).
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
- EC Number:
- 421-320-0
- EC Name:
- 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
- Cas Number:
- 118289-55-7
- Molecular formula:
- Hill formula: C10 H9 Cl2 N O CAS formula: C10 H9 Cl2 N O
- IUPAC Name:
- 6-chloro-5-(2-chloroethyl)-2,3-dihydro-1H-indol-2-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- MOLECULAR FORMULA: C10H9Cl2NO
MOLECULAR WEIGHT: 230.09
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino Rat (Cr1:CD BR,VAF/Plus™)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: 8 weeks
- Weight at study initiation: 222.7 - 230.3 g
- Fasting period before study: Overnight fast
- housed 2 or 3/cage,
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: deionized water containing a small amount of Tween 80 (-3 drops/10 ml).
- Details on oral exposure:
- Following an overnight fast, all rats were given a single oral (gavage) dose of a 100 mg/ml suspension (pH = 4.80) of the compound. The vehicle was deionized water containing a small amount of Tween 80 (-3 drops/10 ml).
- Doses:
- dose level, 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The animals were observed for clinical signs of toxicity for 2 days after dosing and were weighed daily. Each animal was individually marked on the dorsal surface with an innocuous colored dye to facilitate identification. The rats were housed 2 or 3/cage, and the cages were identified with a label containing all pertinent study information. The animals were dosed on 9/16/92 (day 1) and euthanized by carbon dioxide inhalation on 9/18/92 (day 3). All rats were then necropsied
and examined for gross tissue and organ changes. Doses were calculated on a weight basis (i.e., mg compound as supplied/kg); the purity (activity) of the compound (95.6%) was not taken into consideration for dose calculations. The actual concentration and stability of the test suspension used to dose the animals were not determined.
Results and discussion
- Preliminary study:
- N/A
Effect levels
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/5 deaths
- Clinical signs:
- other: CLINICAL OBSERVATIONS: Throughout the test period, all rats were asymptomatic, and their overall body weight gain was essentially normal. There were a few faintly orange-tinged urine stains in the cages on the morning of day 2; thereafter, the urine appea
- Gross pathology:
- GROSS NECROPSY: There were no gross tissue or organ changes observed in any of the rats 2 days after dosing.
at 2000
lungs - dark red
stomachal meteroism
dried blood on the muzzle
intestinal congestion
liver pale
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CONCLUSION: No deaths were produced by an oral dose of 2000 mg/kg.
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