Registration Dossier
Registration Dossier
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EC number: 427-430-5 | CAS number: 54301-26-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- No effect was observed based on an acute dermal toxicity study (OECD 402) with a LDO value > 2000 mg/kg. The substance is not irritant to skin and not a skin sensitizer. A dermal penetration study showed a penetration of the substance formulated at 2% at about 2%.
A 28d oral toxicity study is available and corresponds to the worst case scenario in terms of systemic exposure. Moreover, a route to route extrapolation can be made between oral and dermal.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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