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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1984
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Draize procedure ar 24 hour interval for the first three days after instillation of the compound
Principles of method if other than guideline:
Iohexol was tested by instilling 0.1 gram of the powder into the right eye of each six New Zealand White rabbits (the left eye serving as untreated control). In the three of the six rabbits, the eye were irrigated with 20 ml of water 4 seconds after instillation. The eye were examined and scored by Draize procedure at 24 hour intervals for the first three days after instillation of the compound.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Iohexol
EC Number:
266-164-2
EC Name:
Iohexol
Cas Number:
66108-95-0
Molecular formula:
C19H26I3N3O9
IUPAC Name:
5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
not specified
Controls:
yes
Duration of treatment / exposure:
Three days
Observation period (in vivo):
24 hour
Number of animals or in vitro replicates:
6

Results and discussion

In vitro

Results
Irritation parameter:
in vitro irritation score
Run / experiment:
0,1 gram of powder was tested into the right eye of each of six New Zealand White rabbit (the left eye serving as untreated control)
Value:
ca. 0.1
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
no indication of irritation

Any other information on results incl. tables

Iohexol was tested by instilling 0.1 gram of the powder into the right eye of each six New Zealand White rabbits (the left eye serving as untreated control). In the three of the six rabbits, the eye were irrigated with 20 ml of water 4 seconds after instillation. The eye were examined and scored by Draize procedure at 24 hour intervals for the first three days after instillation of the compound. No irritation was observed in irrigated or non-irrigated eyes.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: other: Draize procedure
Conclusions:
No irritation was observed in irrigated or non-irrigated eyes.
Executive summary:

Iohexol was tested by instilling 0.1 gram of the powder into the right eye of each six New Zealand White rabbits (the left eye serving as untreated control). In the three of the six rabbits, the eye were irrigated with 20 ml of water 4 seconds after instillation. The eye were examined and scored by Draize procedure at 24 hour intervals for the first three days after instillation of the compound. No irritation was observed in irrigated or non-irrigated eyes.