Registration Dossier
Registration Dossier
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EC number: 201-961-0 | CAS number: 90-02-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other: company data
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Salicylaldehyde
- EC Number:
- 201-961-0
- EC Name:
- Salicylaldehyde
- Cas Number:
- 90-02-8
- Molecular formula:
- C7H6O2
- IUPAC Name:
- 2-hydroxybenzaldehyde
- Details on test material:
- Name of test material (as cited in study report): Salicylaldehyde - Physical state: clear, colorless, oily liquid - Analytical purity: over 95 %
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: epicutaneous; drop on
- Vehicle:
- no data
- Concentration / amount:
- 1%
Challenge
- Concentration / amount:
- 1%
- No. of animals per dose:
- 5 animals (In the table attached to the report, the number of animals was 4. For this inconsistency between the text and table, no explanation was given in this report)
- Positive control substance(s):
- yes
- Remarks:
- Phenylhydrazine
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 5.0.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
