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EC number: 201-961-0 | CAS number: 90-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Salicylaldehyde
- EC Number:
- 201-961-0
- EC Name:
- Salicylaldehyde
- Cas Number:
- 90-02-8
- Molecular formula:
- C7H6O2
- IUPAC Name:
- 2-hydroxybenzaldehyde
- Details on test material:
- - Name of test material(as cited in study report): 2-Hydroxybenzaldehyde - Physical state: colorless or pale yellowish clear oil liquid - Analytical purity: 99.9% - Stability under test conditions: stable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crj:CD(SD)IGS
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - Source: Charles River Japan, Inc. - Age at study initiation: 10 weeks old - Weight at study initiation: Female: 235-267 g - Housing: Three animals were housed in a stainless steel cage. - Diet: pellet chow, fasting after 17:00 of the previous day until 3 hrs after administration - Water: ad libitum - Acclimation period: 5 days ENVIRONMENTAL CONDITIONS - Temperature (℃): 22 ± 3℃ - Humidity (%): 55 ± 10 % - Ventilation (per hr): over 10 times/hr - Photoperiod (hrs light / hrs dark): 12 hrs light / 12 hrs dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Administration by gavage was performed using a Teflon stomach tube. The animals were fasted after 17:00 until 3 hrs after administration. They had free access to water. The administration volume was 10 ml / kg b.w.
- Doses:
- Step 1: 300 mg/kg bw; Step 2: 300 mg/kg bw; Step 3: 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 per each step
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations:day 1 (day of administration): time just after administration ~ 1, 2, 4 and 6 hrs after administration day 2: once each at AM and PM after day 3: once at AM - Frequency of weighing: days 1 (before administration), 4, 8 and 15 - Necropsy of survivors performed: yes - Other examinations performed: Necropsy of dead animals
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: approx. lethal dose
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Step 1, 300 mg/kg: No mortality (0/3). Step 2, 300 mg/kg: No mortality (0/3) Step 3, 2000 mg/kg: All died (3/3).
- Clinical signs:
- other: Step 1, 300 mg/kg: No abnormality. Step 2, 300 mg/kg: Soft stool (1/3) Step 3, 2000 mg/kg: Death (3/3, within 24 hrs), Decreased locomotor activity (3/3), Deep respiration (1/3), Diarrhea (2/3), Soiled peritoneal region (2/2)
- Gross pathology:
- 300 mg/kg: No abnormality. 2000 mg/kg (dead animals): No abnormality
Any other information on results incl. tables
GHS classification: Category 4
Table 1 Mortality of female rats treated with2-hydroxybenzaldehyde in the single dose oral toxicity test
Step |
Dose(mg/kg) |
Number ofanimalstreated |
Number of animals that died |
Mortality |
Category(GHS) |
LD50(mg/kg) |
||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 - 15 (days) |
|||||||||||
~ 0.5 |
~ 1 |
~ 2 |
~ 4 |
~ 6 |
~ 24 (hrs) |
|||||||||||||
1 |
300 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/3 |
4 |
500 |
2 |
300 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/3 |
||
3 |
2000 |
3 |
0 |
0 |
1 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3/3 |
Table 2 Clinical signs of female rats treated with 2-hydroxybenzaldehyde in the single dose oral toxicity test
Step |
Dose(mg/kg) |
Findings |
1 |
2 |
3 |
4 -15(days) |
|||||
Grade |
~ 0.5 |
~ 1 |
~ 2 |
~ 4 |
~ 6(hrs) |
||||||
1 |
300 |
Number of animals examined |
|
3 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
Signs |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|||
2 |
300 |
Number of animals examined |
|
3 |
3 |
3 |
3 |
3 |
3 |
3 |
3 |
Soft stool |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|||
3 |
2000 |
Number of animals examined |
|
3 |
3 |
3 |
2 |
1 |
0 |
0 |
0 |
Decreased locomotor activity |
1 |
1 |
1 |
2 |
1 |
0 |
|||||
2 |
0 |
1 |
1 |
0 |
0 |
||||||
Deep respiration |
1 |
0 |
1 |
1 |
0 |
0 |
|||||
Diarrhea |
1 |
0 |
2 |
1 |
0 |
0 |
|||||
Soiled perineal region |
1 |
0 |
0 |
1 |
2 |
1 |
|
|
|
Grade, 1 : Slight; 2 : Moderate
Table 3 Body weight of female rats treated with 2-hydroxybenzaldehyde in the single dose oral toxicity test
Step |
Dose(mg/kg) |
Number ofanimals treated |
Body weights (g) |
|||
1 |
4 |
8 |
15(days) |
|||
1 |
300 |
3 |
225 ± 6 (3) |
256 ± 6 (3) |
263 ± 10 (3) |
266 ± 18 (3) |
2 |
300 |
3 |
223 ± 8 (3) |
254 ± 15 (3) |
263 ± 15 (3) |
276 ± 24 (3) |
3 |
2000 |
3 |
225 ± 6 (3) |
(0) |
(0) |
(0) |
Values represent mean body weight ± S.D. (number of animals examined)
Table 4 Incidence of necropsy findings of female rats treated with 2-hydroxybenzaldehyde in the single dose oral toxicity test
Step |
Dose(mg/kg) |
Findings |
Fate |
|
Terminal kill |
Found dead |
|||
1 |
300 |
Number of animals examined |
3 |
0 |
No abnormalities detected |
3 |
|
||
2 |
300 |
Number of animals examined |
3 |
0 |
No abnormalities detected |
3 |
|
||
3 |
2000 |
Number of animals examined |
0 |
3 |
No abnormalities detected |
|
3 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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