3,3'-oxybis(ethyleneoxy)bis(propylamine)

Endpoint summary

Additional information

The substance is with high probability acutely not harmful to aquatic organisms.

Short-term toxicity to fish

With high probability acutely not harmful to fish (96-h LC50 > 215 - < 464 mg/L; after pH-adjustment 96 -h LC50 > 1000 mg/L)

Long-term toxicity to fish

In Annex IX, Section 9.1.6, Column 2 of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing on fish shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to CLP-Regulation (EC) No 1272/2008 and its second adaptation 286/2011 or is assessed to be a PBT or vPvB.  The hazard assessment of the substance reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment.

In Annex XI, Section 3, it is laid down that testing in accordance with sections 8.6 and 8.7 of Annex VIII and in accordance with Annex IX may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report (“Substance-Tailored Exposure-Driven Testing”). In accordance with Annex XI Section 3, it can be demonstrated in the risk assessment that the manufacture and the use of the substance do not pose an unacceptable risk for all environmental compartments as the risk characterization ratios (RCRs) of the chemical safety assessment are below 1 for all compartments (see Chemical Safety Report Ch. 10).  

Therefore, and for reasons of animal welfare, a long-term toxicity test on fish is not provided.

In addition, the acute-to-chronic ratio (ACR) as determined following the ECETOC Technical Report No. 93 (Aquatic Hazard Assessment II; ECETOC, 2003) shows that a long-term NOEC for fish of > 1 mg/L is to be expected.

Moreover, the results from short-term toxicity tests on fish, Daphnia and algae demonstrate that aquatic invertebrates are the most sensitive trophic level tested. Hence, it may be concluded that results from a long-term fish test would not reveal a greater hazard than already determined by the available data. Therefore and for reasons of animal welfare, a chronic test on fish is not provided.

Short-term toxicity to aquatic invertebrates

With high probability acutely not harmful to aquatic invertebrates (48 -h EC50 = 218.16 mg/L).

Long-term toxicity to aquatic invertebrates

In Annex IX Section 9.1.5 column 2 of Regulation (EC) No 1907/2006, it is laid down that long-term toxicity testing on aquatic invertebrates shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on invertebrates. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or CLP-Regulation (EC) No 1272/2008 or is assessed to be a PBT or vPvB.  The hazard assessment of the substance reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. In Annex XI Section 3, it is laid down that testing in accordance with sections 8.6 and 8.7 of Annex VIII and in accordance with Annex IX may be omitted, based on the exposure scenario(s) developed in the Chemical Safety Report (“Substance-Tailored Exposure-Driven Testing”). In accordance with Annex XI Section 3, it can be demonstrated in the risk assessment that the manufacture and the use of the substance do not pose an unacceptable risk for all environmental compartments as the risk characterization ratios (RCRs) of the chemical safety assessment are below 1 for all compartments (see Chemical Safety Report Ch. 10). Therefore, a long-term toxicity test on aquatic invertebrates is not provided.

In addition, the acute-to-chronic ratio (ACR) as determined following the ECETOC Technical Report No. 93 (Aquatic Hazard Assessment II; ECETOC, 2003) shows that a long-term NOEC for daphnids of > 1 mg/L is to be expected.

Toxicity to aquatic algae

With high probability acutely not harmful to aquatic algae (72 -h ErC50 > 500 mg/L; 72 -h ErC10 = 31.3 mg/L; 72 -h ErC10 = 31.3 mg/L; based on not pH-adjusted test solutions).

Toxicity to microorganisms

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations (17 -h NOEC = 125 mg/L, not neutralised).