Ethyltriphenylfosfonium bromide

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to fish, other

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from ECOSAR version 1.11

Qualifier:

according to guideline

Guideline:

other: Modelling database

Principles of method if other than guideline:

Long term toxicity to fish was carried out according to the ECOSAR version 1.11

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fish

Test type:

static

Water media type:

freshwater

Total exposure duration:

28 d

Reference substance (positive control):

not specified

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

0.156 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: ECOSAR version 1.11

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.156 mg/l for fish for 28 days of exposure duration

Executive summary:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static fresh water system, the NOEC value for the substance is estimated to be 0.156 mg/l for fish for 28 days of exposure duration.Based on the NOEC value it can be concluded that the test chemical is toxic to fish at environmentally relevant concentrations and can be considered aquatic cronic 2 as per the CLP classification criteria. 

Description of key information

Long term toxicity to fish:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static fresh water system, the NOEC value for the substance is estimated to be0.156mg/l for fish for 28 days of exposure duration.Based on the NOEC value it can be concluded that the test chemical is toxic to fish at environmentally relevant concentrations and can be considered aquatic cronic 2 as per the CLP classification criteria. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

0.156 mg/L

Additional information

Long term toxicity to fish:

Long term toxicity for test substance was evaluated using prediction for the test material and another data from authorative database:

1)Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static fresh water system, the NOEC value for the substance is estimated to be0.156mg/l for fish for 28 days of exposure duration.Based on the NOEC value it can be concluded that the test chemical is toxic to fish at environmentally relevant concentrations and can be considered aquatic cronic 2 as per the CLP classification criteria. 

2)Long term toxicity of test material was performed on fish for 21 days according to OECD Guideline 204. 20 test animals per vessele were treated , the test concentation used for the evaluation of toxicity were 0.041, 0.092, 0.204, 0.479, 1.100, 2.546 mg/L (geometric ratio: 2.3). The no effect concentration (NOEC) was observed to be 0.18 mg/l after 21 days of exposure of test material on fish .Effect concentration was indicated based on arithmetic mean values of measurement concentrations, because some analysis results exceeded ±20 % of nominal concentrations in concentration areas.

Based on the above NOEC value it can be concluded that test substance is toxic to fish in the long term and can be classified as aquatic chronic 2 as per CLP