Registration Dossier

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: oral
Remarks:
other: subacute and subchronic
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no guideline study, only form secondary literature, source: US OSHA

Data source

Reference
Reference Type:
secondary source
Title:
Occupational Safety and Health Guideline for Tin Oxide
Author:
US OSHA
Year:
1994
Bibliographic source:
http://www.osha.gov/SLTC/healthguidelines/tinoxide/recognition.html

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
guideline unknown
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: feed
Vehicle:
not specified
Details on oral exposure:
no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 and 13 wks
Frequency of treatment:
daily with food
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
0.03
Basis:
other: percent of feed
Remarks:
Doses / Concentrations:
0.1
Basis:
other: percent of feed
Remarks:
Doses / Concentrations:
0.3
Basis:
other: percent of feed
Remarks:
Doses / Concentrations:
1.0
Basis:
other: percent of feed
No. of animals per sex per dose:
no data
Control animals:
yes, concurrent no treatment

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No adverse effects following 4 and 13 weeks of exposure, toxicity criteria used in the study included body weight change, diet utilization, organ weights, mortality, and blood, urine, or biochemical parameter changes

Applicant's summary and conclusion

Conclusions:
No adverse effects following 4 and 13 weeks of exposure, toxicity criteria used in the study included body weight change, diet utilization, organ weights, mortality, and blood, urine, or biochemical parameter changes, highst dose: 1 % in feed