Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study before guideline and glp time
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1975
Report Date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
yes
Remarks:
dose selection
Principles of method if other than guideline:
study from 1975, comparable with OECD 423; dose selection see point doses
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
fasted (no food 16-18hrs before application): 600, 1200, 1800, 2400, 4800 mg/kg bw
feed: 1500, 1800, 3000, 6000 mg / kg /bw
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 274.6 mg/kg bw
Based on:
other: SnCl_2 * H2O
95% CL:
> 1 613.2 - < 3 207.2
Remarks on result:
other: fasted rats
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3 190.1 mg/kg bw
Based on:
other: SnCl_2 *H2O
95% CL:
> 2 044.9 - < 4 976.6
Remarks on result:
other: feeded tats

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for stannous dichloride dihydrate was determined to be 2274.6 mg/kg bw. Form this value the LD50 for stannous chloride form 1910.1 mg/kg bw was calculated.