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EC number: 202-681-1 | CAS number: 98-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Patch test
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chloro-α,α,α-trifluorotoluene
- EC Number:
- 202-681-1
- EC Name:
- 4-chloro-α,α,α-trifluorotoluene
- Cas Number:
- 98-56-6
- Molecular formula:
- C7H4ClF3
- IUPAC Name:
- 1-chloro-4-(trifluoromethyl)benzene
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Parachlorbenzotrifluorid
- Physical state: colourless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1,5 -2,0 kg
- Housing: individually caged
- Diet: ERKA 8300 ad libitum
- Water: ad libitum
IN-LIFE DATES: From: 3 February To: 7 February
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: sesame oil
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted
- Amount(s) applied (volume or weight with unit): 10% diluted - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: right flank for undiluted product application, left flank for diluted product application
-Area of coverage: 2.5 x 2.5 cm
- Type of wrap if used: surgical gauze wrapped by PVC sheet and fixed by adhesive tape
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h
SCORING SYSTEM: Federal Register 38, N. 187 (27/09/1973), cap. 1500.41
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal: 12
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- edema score
- Basis:
- animal: 5
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- edema score
- Basis:
- animal: 3
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- edema score
- Basis:
- animal: 2
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- edema score
- Basis:
- animal: 1
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- erythema score
- Basis:
- animal: 12
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal: 2
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- not fully reversible within: 96 h
- Irritation parameter:
- erythema score
- Basis:
- animal: 1, 3, 5
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Non irritant and non corrosive
Any other information on results incl. tables
Application on right flank (undiluted product)
Animal N. |
Skin Reaction |
24 hs after Application |
48 hs after Application |
72 hs after Application |
96 hs after Application |
Sum |
||||
Intact |
Scarified |
Intact |
Scarified |
Intact |
Scarified |
Intact |
Scarified |
24+72 (1+5+6) |
||
1 |
Erythema Oedema |
1 2 |
1 1 |
0 1 |
1 0 |
0 0 |
0 0 |
|
|
5 |
2 |
Erythema Oedema |
1 4 |
1 3 |
1 2 |
1 1 |
1 1 |
1 0 |
|
|
12 |
3 |
Erythema Oedema |
1 3 |
1 3 |
0 2 |
1 2 |
0 2 |
0 2 |
|
|
12 |
4 |
Erythema Oedema |
0 3 |
0 1 |
0 2 |
0 1 |
0 1 |
0 1 |
|
|
6 |
5 |
Erythema Oedema |
1 2 |
1 1 |
0 1 |
1 0 |
0 1 |
1 0 |
|
|
7 |
12 |
Erythema Oedema |
0 1 |
0 1 |
0 1 |
0 1 |
0 0 |
0 1 |
|
|
3 |
Application on left flank (diluted product)
Animal N. |
Skin Reaction |
24 hs after Application |
48 hs after Application |
72 hs after Application |
96 hs after Application |
Sum |
||||
Intact |
Scarified |
Intact |
Scarified |
Intact |
Scarified |
Intact |
Scarified |
24+72 (1+5+6) |
||
1 |
Erythema Oedema |
0 0 |
1 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
|
1 |
2 |
Erythema Oedema |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
|
|
0 |
3 |
Erythema Oedema |
0 1 |
1 1 |
0 0 |
0 1 |
0 0 |
1 0 |
|
|
4 |
4 |
Erythema Oedema |
0 1 |
0 0 |
0 1 |
0 0 |
0 0 |
0 0 |
|
|
1 |
5 |
Erythema Oedema |
0 0 |
1 0 |
0 0 |
0 0 |
0 0 |
1 0 |
|
|
2 |
12 |
Erythema Oedema |
0 0 |
0 1 |
0 0 |
0 0 |
0 0 |
0 0 |
|
|
1 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- The test item results non irritating and non corrosive to skin.
- Executive summary:
The test item was applied to the skin of the flank of 6 rabbits, through occlusive coverage. The right flank was treated with the undiluted product, while the left flank was treated with the 10% dilution of the product in sesame oil. The exposure time was 24 hours; the observation period was up to 72 hs. The irritation index was calculated based on erythema and oedema scores after 24 and 72 hours and it was found to be 1.9 for the undiluted product and 0.4 for the dilution. It is concluded that the test item is not irritating nor corrosive to skin.
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