Registration Dossier
Registration Dossier
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EC number: 228-510-0 | CAS number: 6284-83-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Danish QSAR database
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR prediction
- GLP compliance:
- no
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 1.041 - <= 4.161 mg/L
- Conc. based on:
- test mat.
- Details on results:
- See tables of results
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Annex III inventory; DEMETRA Daphnia Magna toxicity model in VEGA (Q)SAR platform
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR prediction
- GLP compliance:
- no
- Total exposure duration:
- 48 h
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.803 mg/L
- Conc. based on:
- test mat.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- DEMETRA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.8033 mg/L (good reliability)
Referenceopen allclose all
Aquatic toxicity
| Exp | Battery | Leadscope | SciQSAR |
Daphnia magna 48h EC50 (mg/L) |
| 1.08824 | 1.040806 | 1.135674 |
Domain |
| IN | IN | IN |
DTU-developed models | ||||
| Daphnid 48h |
LC50 (Fish) or EC50 (Daphnid and Algae) for Most Toxic Class (mg/L) | 4.161 |
Max. Log Kow for Most Toxic Class | 5 |
Most Toxic Class | Polynitrobenzenes |
EPI ECOSAR models | |
ECOSAR Classes: Polynitrobenzenes | |
Description of key information
Several data were available for this endpoint, coming from the following sources:
- Annex III inventory from ECHA, with a value provided by the VEGA (Q)SAR platform
- Danish QSAR Database, reporting predictions from DTU-developed and EPI ECOSAR models.
All data range between 0.8 and 4.2 mg/L.
An 48h-EC50 value of 0.8 mg/L is considered as the key value for that endpoint as it is the worst-case result among all predictions and indicated as having a good reliability in the Annex III inventory from ECHA.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 0.8 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
