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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
see attached justification

Data source

Reference
Reference Type:
publication
Title:
TOXICOLOGICAL PROFILE FOR PERCHLORATES
Year:
2008
Bibliographic source:
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
Agency for Toxic Substances and Disease Registry

Materials and methods

Principles of method if other than guideline:
In vitro test for SOS-inducing activity in S. typhimurium (Nakamura and Kosaka 1989);
tests for mutagenicity in various Salmonella strains (Zeiger et al. 1998a)
Guideline not reported.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
perchlorate
Cas Number:
14797-73-0
Molecular formula:
ClO4 -
IUPAC Name:
perchlorate

Method

Metabolic activation:
not specified

Results and discussion

Test results
Species / strain:
S. typhimurium, other: not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Studies in vivo found no evidence of mutagenicity for perchlorate.