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EC number: 241-443-1 | CAS number: 17418-59-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 June 2021 to 30 June 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.096 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 7.049 - <= 7.226
- Details on results:
- It was judged that the test results were valid because maximum difference of the concentration was less than 30 %.
- Conclusions:
- Under the conditions of this study the water solubility of the test material is 0.0959 mg/L at 20 °C.
- Executive summary:
The water solubility of the test material was determined in accordance with the standardised guidelines EU Method A. 6, OECD 105 and EPA OPPTS 830.7840 in compliance with GLP, following the column elution method. The method is based on the elution of the test material with water from a micro-column, which is charged with an inert support material coated with an excess of test material. The water solubility is determined when the mass concentration of the eluate is constant. This is shown by a concentration plateau as a function of time.
Under the conditions of this study the water solubility of the test material is 0.0959 mg/L at 20 °C.
Reference
The measured concentrations of the test material using two different flow rates, the mean concentration and relative standard deviation
| Flow Rate | Concentration, μg/mL |
| 25 mL/h | 0.0767 |
| 12.5 mL/h | 0.115 |
| Mean: | 0.0959 |
| RSD: | 28% |
Description of key information
The water solubility of the test material is 0.0959 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.096 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in accordance with the standardised guidelines EU Method A. 6, OECD 105 and EPA OPPTS 830.7840 in compliance with GLP, following the column elution method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The method is based on the elution of the test material with water from a micro-column, which is charged with an inert support material coated with an excess of test material. The water solubility is determined when the mass concentration of the eluate is constant. This is shown by a concentration plateau as a function of time.
Under the conditions of this study the water solubility of the test material is 0.0959 mg/L at 20 °C.
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