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EC number: 241-443-1 | CAS number: 17418-59-6
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 September 2021 to 16 September 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Specific details on test material used for the study:
- The test material was used in its initial form.
- Key result
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Test no.:
- #2
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- Under the conditions of the test, the vapour pressure of the test material was determined to be 1.870 x 10^-9 Pa at 20°C.
- Executive summary:
The determination of the vapour pressure of the test material was determined according to EU Method A.4, OECD 104 and EPA OPPTS 830.7950 guidlines in compliace with GLP using the Knudsen cell Effusion method. This method is based on the estimation of the mass of test material flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice under ultra-vacuum conditions. The mass of effused vapour can be obtained by determining the loss of mass of the cell. The vapour pressure is calculated by the software of the Vapor Pressure Analyzer applying the Hertz-Knudsen relation with correction factors that depend on parameters of the apparatus.
Under the conditions of the test, the vapour pressure of the test material was determined to be 1.870 x 10^-9 Pa at 20°C.
Reference
The vapour pressure was measured in the temperature range of 140 to 190 °C. For the evaluation the vapour pressure values in the range of 150 to 190 °C were used. The measured vapour pressure values together with the measured temperatures and the regression data of the vapour pressure curve can be seen in the tables below.
Results of the Effusion method
| Temperature, °C | Δm/Δt, mg/min | Vapour pressure, Pa |
| 150.0 | 1.8729 x 10^-4 | 3.5858 x 10^-2 |
| 160.0 | 4.0506 x 10^-4 | 7.8463 x 10^-2 |
| 170.0 | 8.8800 x 10^-4 | 1.7399 x 10^-1 |
| 180.0 | 2.2874 x 10^-3 | 4.5320 x 10^-1 |
| 190.0 | 4.3696 x 10^-3 | 8.7524 x 10^-1 |
Regression data of the vapour pressure curve
| Intercept | Slope | R. Squared |
| 14.9116 | -6930.0005 | 0.9974 |
The vapour pressure of the test material was estimated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C:
Vapour pressure of test material at 20 °C: 1.870 x 10^-9 Pa
Vapour pressure of test material at 25 °C: 4.659 x 10^-9 Pa
Description of key information
Under the conditions of the test, the vapour pressure of the test item was determined to be 1.870 x 10^-9 Pa at 20°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
The determination of the vapour pressure of the test material was determined according to EU Method A. 4, OECD 104 and EPA OPPTS 830.7950 guidlines and in compliace with GLP using the Knudsen cell Effusion method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The Knudsen cell Effusion method is based on the estimation of the mass of test material flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice under ultra-vacuum conditions. The mass of effused vapour can be obtained by determining the loss of mass of the cell. The vapour pressure is calculated by the software of the Vapor Pressure Analyzer applying the Hertz-Knudsen relation with correction factors that depend on parameters of the apparatus.
Under the conditions of the test, the vapour pressure of the test material was determined to be 1.870 x 10^-9 Pa at 20°C.
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