2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-10-19 to 2018-10-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 157.1

Version / remarks:

CIPAC Handbook Volume F, “Physico chemical Methods for Technical and Formulated Pesticides”, W. Dobrat and A. Martijn (1995)
 

GLP compliance:

no

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide

Cas Number:

212070-45-6

Molecular formula:

C36H73NO5

IUPAC Name:

2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide

Test material form:

solid: crystalline

Specific details on test material used for the study:

white, crystalline powder

Results and discussion

Water solubility

Key result

Water solubility:

< 10 mg/L

Conc. based on:

test mat.

Incubation duration:

> 10 - < 15 min

Temp.:

23.6 °C

Remarks on result:

other: for this preliminary test pH was not measured

Remarks:

graduated cylinder

Details on results:

The water solubility of the test item was determined at approx. 23.6 °C to be < 10 mg/L.
For details, please see section “any other information on results incl. tables”.

Any other information on results incl. tables

Test Temperature

Table 1: Temperature Data

Test	Temperature [°C]
	Min.	Max.	Mean
Graduated cylinder	22.1	23.6	22.851
Bottles	*	*	23.26

*The weather logger stopped by technical difficulties after 15 min.

Test with Graduated Cylinders

Table 2: Results of the Preliminary Test for Water ( 10 mg at max. 100 mL)

Test item (nominal 10 mg) [mg]	Volume of water, type I, mL	Test item concentration (nominal) [g/L]	Homogenous solution (visual) [yes/no]
11	1	11 (11000)	no
	5	2.2 (2200)	no
	10	1 (1000)	no
	20	0.55 (550)	no
	50	0.22 (220)	no
	80  100	0.1375 (137.5) 0.11 (110)	no no

Table 3: Results of the Preliminary Test with Bottles (24 h-stirring, 100 rpm)

Test item (nominal 10 mg) [mg]	Volume of water, type I, mL	Test item concentration (nominal) [mg/L]	Homogenous solution (visual) [yes/no]
10.3	100	103	no
10.0	250	40	no
10.7	500	21.4	no
10.9	1000	10.9	no^1

1) Still no homogenous solution after additional stirring for 21 h at room temperature; not even a significant amount of the used test item was observed to be dissolved

 

 

 

Applicant's summary and conclusion

Conclusions:

The water solubility of the test item at approx. 23.6 °C was < 10 mg/L.

Executive summary:

The water solubility of Ceramide VI was determined via shaking method followed by visual check according to CIPAC MT 157.1 (CIPAC Handbook Volume F, “Physico chemical Methods for Technical and Formulated Pesticides”, W. Dobrat and A. Martijn (1995)).

No dissolution was observed at any time point of the study.

The water solubility of Ceramide VI was determined to be < 10 mg/L at 23.6 °C.