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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-04-24 to 1986-06-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4500 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- EC Number:
- 405-520-5
- EC Name:
- 4-(4-isopropoxyphenylsulfonyl)phenol
- Cas Number:
- 95235-30-6
- Molecular formula:
- C15H16SO4
- IUPAC Name:
- 4-[4-(propan-2-yloxy)benzenesulfonyl]phenol
- Details on test material:
- - Name of test material (as cited in study report): D - 8
- Molecular formula: C15 H16 O4 S;
- Molecular weight: 292.4;
- Physical state: white powder;
- Analytical purity: > 99.5 %;
- Purity test date: not stated;
- Lot/batch No.: Not stated;
- Expiration date of the lot/batch: not stated;
- Stability under test conditions: stable at ambient temperature and conditions;
- Storage condition of test material: store in a cool dry place, protected from direct sunlight;
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Rabbits; Petersfield, Hampshire; England;
- Age at study initiation: approximately 11 to 12 weeks;
- Weight at study initiation: 2.4 to 2.7 kg;
- Housing: individually in metal cages with perforated floors;
- Diet: SDS Standard Rabbit Diet ad libitum;
- Water: tap water ad libitum;
- Acclimation period: not stated;
ENVIRONMENTAL CONDITIONS
- Temperature: approximately 19 °C;
- Humidity: 30 - 70 % R.H.;
- Air changes: approximately 19 air changes/min;
- Photoperiod: 12 hours light/12 hours dark;
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 33 mg occupying a volume of 0.1 mL
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 males
- Details on study design:
- The eyes of each animal were examined prior to instillation of the test substance to ensure that there was no pre-existing corneal damage or conjunctival inflammation.
A 33 mg amount of D-8, the weight occupying a volume of 0.1 mL, was placed into the lower everted lid of one eye of each animal.
The eyelids were then gently hold together for one second before releasing. The contralateral eye remained untreated and served as a control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Instillation of D-8 into the rabbit eye did not elicit a positive response in any of the six treated animals according to the T.S.C.A. test criteria.
- Other effects:
- No other effects observed.
Any other information on results incl. tables
None of the animals gave a positive response.
No corneal damage or iridial inflammation was observed in any of the animals.
Transient mild conjunctival reactions were seen in five animals.
The eyes were normal two or three days after instillation.
One animal did not show any observable response to treatment throughout the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- D-8 was tested for eye irritation in rabbits according to the US EPA TSCA guideline 798.4500. Instillation of D-8 into the rabbit eye did not elicit a positive response in any of the six treated animals according to T.S.C.A. test criteria. Therefore, D-8 was considered non-irritant to the rabbit eye.
- Executive summary:
D-8 was tested for eye irritation according to test criteria in compliance with the guidelines of the US EPA Toxic Substance Control Act (TSCA). None of the tested animals gave a "positive" response. No corneal damage or iridial inflammation was observed in any of the animals. Transient mild conjunctival reactions were seen in five animals, with eyes normal two or three days after instillation. One animal did not show any observable response to treatment throughout the observation period. Therefore, according to the T.S.C.A. test criteria, D-8 was not considered to cause eye irritation effects.
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