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Diss Factsheets
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EC number: 946-383-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed to a recognised guideline in accordance with generally accepted scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: I.R.L.G. Guidelines method
- Deviations:
- yes
- Remarks:
- see below
- Principles of method if other than guideline:
- Two rabbits per sex were dosed on the dorsal area (240 cm2) abraded and dosed at 2.0 mL/kg undiluted material. Covered with porous gauze dressing and a semi-occlusive wrapping of polyethylene. Rabbits restrained in hood facing outward for 24-hour contact period to avoid their inhaling any volatiles. The IRLG guidelines recommend a semi-occlusive sheeting and no immobilisation during the contact period.
The animals were observed for 14 days. - GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 2-Ethylhexyl N-(5-isocyanato-2-methylphenyl)carbamate and 2-Ethylhexyl N-(3-isocyanato-4-methylphenyl)carbamate and N,N'-(4-Methyl-1,3-phenylene)bis(carbamic acid) C,C'-bis(2-ethylhexyl) ester
- EC Number:
- 937-955-6
- Molecular formula:
- components with the molecular formulae C25H42N2O4 and C17H24N2O3
- IUPAC Name:
- Reaction mass of 2-Ethylhexyl N-(5-isocyanato-2-methylphenyl)carbamate and 2-Ethylhexyl N-(3-isocyanato-4-methylphenyl)carbamate and N,N'-(4-Methyl-1,3-phenylene)bis(carbamic acid) C,C'-bis(2-ethylhexyl) ester
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): Appropriate Wayne diet ad libitum.
- Water (e.g. ad libitum): ad libitum.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240cm^2
- Type of wrap if used: porous gauze dressing covered by a semi occlusive polyethylene wrapping
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2mL/kg
VEHICLE
N/A - Duration of exposure:
- 24 hours.
- Doses:
- 2.0 mL/kg.
- No. of animals per sex per dose:
- 2 animals per sex per dose.
- Control animals:
- no
- Details on study design:
- Dorsal area (240 cm2) abraded and dosed at 2.0 mL/kg undiluted material. Covered with porous gauze dressing and a semi-occlusive wrapping of polyethylene. Rabbits restrained in hood facing outward for 24-hour contact period to avoid their inhaling any volatiles.
The animals were observed for 14 days.
LD50 was calculated by probit transformation based on 14 days of observation.
Observations were made during this time to assess skin reactions and bodyweight changes.
At the end of the observation period, animals were necropsied. - Statistics:
- Not reported
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 95%CL not reported
- Mortality:
- No deaths occured during the study.
- Clinical signs:
- other: Skin damage caused by the manipulative trauma of removing the gauze and sheeting at 24 hours. Scabbing over of skin injuries at 48 hours. Soft stool noted on various days throughout the 14-day observation period.
- Gross pathology:
- Rough edges on liver (2 females); spleen injected (1 female); upper right lung lobe dark red after washing (1 male)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD 50 of the substance was determined to be >2.0 mL/kg; undiluted.
- Executive summary:
The skin penetration of the test material was investigated in a single dose in accordance with Modified I.R.L.G. Guidelines method. (1979).
Two rabbits per sex dosed on abraded skin at 2.0 mL/kg of the undiluted material had moderate to marked capillary injection as a result of the 24-hour application under semi-occlusive polyethylene sheeting. At the end of the 14-day observation period, all animals had gained weight. No mortality was seen.
LD50 > 2.0 mL/kg; undiluted
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