1,6-Bis(methoxybenzoyloxy)hexane

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Study period:

February 2004

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

yes

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
not applicable

Radiolabelling:

not specified

Analytical monitoring:

not specified

Details on sampling:

Not applicable

Buffers:

Not applicable

Positive controls:

not specified

Negative controls:

not specified

Preliminary study:

The water solubility of Setfaxi X11342 was determined to be 0.0000088g/L (see NOTOX Project 330918: determination fo water solubility of Setafix X 11342). Based on this water solubility, the hydrolysis test has to be performed at a maximum concentration of 0.0000044g/L..
In the hydrolysis test, concentrations have to be measured accurately in order to draw reliable conclusions on hydrolysis rate. At concentrations <0.0000044g/L, the analytical method used during NOTOX project 330918 is not sufficiently accurate. Development of a sufficiently accurate method is expected not possible.
Based on this, it is concluded that the test cannot be supported analytically and therefore cannot be performed.

Transformation products:

not measured

Validity criteria fulfilled:

not specified

Conclusions:

The water solubility of Setfaxi X11342 was determined to be 0.0000088g/L (see NOTOX Project 330918: determination fo water solubility of Setafix X 11342). Based on this water solubility, the hydrolysis test has to be performed at a maximum concentration of 0.0000044g/L..
In the hydrolysis test, concentrations have to be measured accurately in order to draw reliable conclusions on hydrolysis rate. At concentrations <0.0000044g/L, the analytical method used during NOTOX project 330918 is not sufficiently accurate. Development of a sufficiently accurate method is expected not possible.
Based on this, it is concluded that the test cannot be supported analytically and therefore cannot be performed.

Executive summary:

Based on the interpretation of the available data, it is concluded that the test cannot be supported analytically and therefore cannot be performed.

Description of key information

The water solubility of Setafix X11342 was determined to be 0.0000088g/L (see NOTOX Project 330918: determination of water solubility of Setafix X 11342). Based on this water solubility, the hydrolysis test has to be performed at a maximum concentration of 0.0000044g/L..
In the hydrolysis test, concentrations have to be measured accurately in order to draw reliable conclusions on hydrolysis rate. At concentrations <0.0000044g/L, the analytical method used during NOTOX project 330918 is not sufficiently accurate. Development of a sufficiently accurate method is expected not possible.
Based on this, it is concluded that the test cannot be supported analytically and therefore cannot be performed.