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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
yes
Type of method:
estimation method (solubility ratio)
Analytical method:
other: visual assessment
Key result
Type:
log Pow
Partition coefficient:
> 4.3
Remarks on result:
other: pH and temperature not stated

- The octanol solubility was visually seen to be > 1000 g/L.

- Previously determined water solubility was used for calculation of the partition coefficient.

Conclusions:
The Pow value of the test item was estimated to be > 2.16 x 10E+04, which corresponds to a Log Pow value of > 4.3.
Executive summary:

METHODS

Since the test item is a surface active UVCB (estimated surface tension of 48 nM/m), neither the Shake Flask method nor the HPLC method are recommended. Therefore, the estimation method was performed.

 

RESULTS

The Pow value of the test item was estimated to be > 2.16 x 10E+04, which corresponds to a Log Pow value of > 4.3.

Description of key information

The Pow value of the test item was estimated to be > 2.16 x 10E+04, which corresponds to a Log Pow value of > 4.3 (EU Method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
4.3
at the temperature of:
25 °C

Additional information

GUIDELINE

Since the test item is a surface active UVCB (estimated surface tension of 48 nM/m), neither the Shake Flask method nor the HPLC method are recommended. Therefore, the estimation method was performed.

 

RESULTS

The Pow value of the test item was estimated to be > 2.16 x 10E+04, which corresponds to a Log Pow value of > 4.3.