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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral LD50 (rat)
Acute oral LD50 (hampster)
Acute dermal LD50 (rat)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. 312-187 - Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in house
- Age at study initiation: 7 - 8 weeks
- Fasting period before study: overnight
- Housing: groups of 5 in Macrolon cages (type 3)
- Diet (e.g. ad libitum): NAFAG No. 890, NAFAG, Gossau SG, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 deg C
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 12 / 12
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- TK 12184 was suspended to achieve a concentration suitable for the dose levels selected for this test.
Volume (ml/kg body-weight): 10, 20 - Doses:
- 1000, 2500, 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were observed over a period of 14 days following dosing.
Bodyweights were recorded immediately prior to dosing and at 7 and 14 days.
All animals were submitted to a necropsy. - Statistics:
- The LD50, including tne 95 % confidence limits were calculated by the logit model.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 313 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 404 - 5 333
- Mortality:
- 1000 mg/kg: no deaths
2500 mg/kg: 1 female
5000 mg/kg: 4 males and 5 females - Clinical signs:
- Surviving animals recovered within 7 to 8 days
- Gross pathology:
- No compound related gross organ changes were observed.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not classified by CLP criteria
- Conclusions:
- Under these standard test conditions, the acute oral LD50 of TK 12184 in rats of both sexes observed over a period of 14 days is 3313 (2404-5333) mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12184
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6 - Species:
- hamster, Chinese
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in house
- Weight at study initiation: males - 32 g; females - 32 g
- Fasting period before study: overnight
- Housing: Indlvldually In Macrolon cages (type 2)
- Diet (e.g. ad libitum): NAFAG No. 923/924 NAFAG, Gossau SG, ad libitum
- Water (e.g. ad libitum): ad libitim
- Acclimation period: mlnlmum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 deg C
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 12 / 12 - Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- TK 12184 was suspended in distrilled water to achleve a concentratlon suitable for the dose levels selected.
Dosage volume: 10 mL/kg - Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Physlcal condltion and rate of deaths were monltored throughout the whole observatlon perlod.
Body welghts were recorded immedlately prlor to doslng and at 7 and 14 days.
All anlmals were submltted to a necropsy. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred
- Clinical signs:
- All anlmals recovered wlthln 7 days.
- Body weight:
- Mean body weights decreased during the study.
- Gross pathology:
- No gross organ changes were observed.
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not classified by CLP criteria
- Conclusions:
- Under these standard test conditions, the acute oral LD50 of TK 12184 in Chinese hamsters of both sexes observed over a period of 14 days is >3,000 mg/kg.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 313 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. 312-187 - Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in house
- Weight at study initiation: males - 211 g; females - 195 g
- Housing: individually in Macrolon cages (type 2)
- Diet (e.g. ad libitum): NAFAG No. 890 NAFAG, Gossau S6, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 deg C
- Humidity (%): 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 12 / 12 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approximately 24 hours before treatment an area on the back of the rats of approximately 60 square cm was shaved with an electric clipper. For treatment the test material was evenly dispersed on the skin with a syringe and was covered with an occlusive dressing which was fastened around the trunk with an adhesive elastic bandage. After 24 hours the dressing was removed, the skin was cleaned with lukewarm water and the reaction of the skin was appraised.
- Duration of exposure:
- 24 h
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were observed over a period of 14 days after dosing.
Bodyweights were recorded immediately prior to dosing and at 7 and 14 days.
Animals were submitted to a necropsy at the end of the observation period. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- All animals recovered from systemic symptoms within 8 days.
- Body weight:
- Body weights increased during the study
- Gross pathology:
- No gross ogan changes were seen
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not classified by CLP criteria
- Conclusions:
- Under these standard test conditions, the acute dermal LD50 of TK 12 184 in rats of both sexes observed over a period of 14 days is greater than 3000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute oral LD50 (rat) = 3313 mg/kg
Acute oral LD50 (hampster) > 3000 mg/kg
Acute dermal LD50 (rat) > 3000 mg/kg
Justification for classification or non-classification
Based on the available data, TGEPO is not classified as according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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