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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- other: Norme Experimentale AFNOR T 90-301.
- Deviations:
- yes
- Remarks:
- TK 12 184 is not water soluble; stable suspensions were used
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184; trade name D 16-51
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. Mixt. 4/5/6
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature (20 - 24 deg C) - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- TK 12 184 was not sufficiently water soluble for the preparation of a 100 mg/L aqueous stock solution. A Suspension of 100 mg/L TK 12 184 in water with an acceptable stability was obtained applying 400 W ultrasound during 4 minutes.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain/clone: Daphnia magna Straus 1820
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: Animals retained on the 560 pm mesh sieve (sieved 24 h before the test and the day of test) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- pH:
- 8.0
- Dissolved oxygen:
- O2 = 8.45 mg/L (99 % of Saturation) 22 deg C. There is no valid explanation for the observed oversaturation of oxygen at the end of the test.
- Nominal and measured concentrations:
- Nominal: 6.2, 8, 10, 13, 17, 22, 29, 37, 48 mg/L
- Details on test conditions:
- Vessels: 10 ml test-tubes, covered with stainless-steel cups
Diluent: reconstituted water
Number of organisms per vessel: 5
Replicates: 4 replicates per test concentration
Temperature: 20 + 1 deg C
Lighting: darkness - Reference substance (positive control):
- yes
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 12.54 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Corrected with the bichromate value
- Results with reference substance (positive control):
- The IC50 (24 h) of the Bichromate was calculated as 1.1 mg/L.
- Conclusions:
- Under these test conditions, the IC50 (24 h) for TK 12 184 in Daphna magna, corrected with the Bichromate-value, was calculated as 12.54 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- Results predicted by US EPA ECOSAR v1.11 model.
- GLP compliance:
- no
- Details on results:
- No effects are expected at saturated concentrations in water. The estimated logKow for this substance is greater than the class specific cut-offs for acute Daphnid toxicity, and the predicted effect level exceeds the water solubility of this substance by more than 10x.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for acute Daphnid toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
Referenceopen allclose all
Description of key information
The IC50 (24 h) for water suspensions of TK 12 184 in Daphna magna, corrected with the Bichromate-value, was calculated as 12.54 mg/L. Water suspensions were prepared with the aid of high speed mixing due to the very low water solubility of the test substance.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 12.54 mg/L
Additional information
The US EPA ECOSAR v1.11 model predicts no effects at saturated concentrations in water for TGEPO (CAS No. 83547-95-9). The estimated logKow for this substance is greater than the class specific cut-offs for acute Daphnid toxicity, and the predicted effect level exceeds the estimated water solubility of this substance by more than 10x.
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