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EC number: 201-744-0 | CAS number: 87-41-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 5 animals was treated by single gavage application with an 0.5% CMC aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated on the basis of the observed mortalities.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Phthalide
- EC Number:
- 201-744-0
- EC Name:
- Phthalide
- Cas Number:
- 87-41-2
- Molecular formula:
- C8H6O2
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1-one
- Details on test material:
- - Name of test material (as cited in study report): Phthalid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 209 g (mean); females: 164 g (mean)
- Diet: Altromin R1324 (Altromin GmbH, Germany), ad libitum
- Water: tap water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 21.5, 31.6, 38.3, 46.4, and 50%
MAXIMUM DOSE VOLUME APPLIED: 20 mL - Doses:
- 2150, 3160, 3830, 4640, 5620, 6810 and 10000 mg/kg bw
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of application and daily thereafter
- Frequency weighing: days 0, 3, 7 and 13
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 600 mg/kg bw
- Mortality:
- 10000 mg/kg bw: all animals died within 1 h and 24 h
6810 mg/kg bw: all animals died within 1 h and 24 h
5680 mg/kg bw: 2/5 males and 2/5 females died within 24 h
4640 mg/kg bw: no mortalities
3830 mg/kg bw: 1/5 males died within 24 h
3160 mg/kg bw: 2/5 males and 1/5 females died within 24 h - Clinical signs:
- other: Dyspnoea, apathy, abdominal-lateral position, partially tumbling, atony, narcotic state with unusual pain and corneal reflex, exsiccosis, salivation, bad general condition.
- Gross pathology:
- Animals that died during the study:
Heart: acute dilatation of the right ventricle; acute congestion;
Sacrificed animals: no macroscopic abnormalities at necropsy.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) |
Gender |
24 h |
48 h |
14 days |
10000 |
m |
5/5 |
5/5 |
5/5 |
f |
5/5 |
5/5 |
5/5 |
|
6810 |
m |
5/5 |
5/5 |
5/5 |
f |
5/5 |
5/5 |
5/5 |
|
5680 |
m |
2/5 |
2/5 |
2/5 |
f |
2/5 |
2/5 |
2/5 |
|
4640 |
m |
0/5 |
0/5 |
0/5 |
f |
0/5 |
0/5 |
0/5 |
|
3830 |
m |
1/5 |
1/5 |
1/5 |
f |
0/5 |
0/5 |
0/5 |
|
3160 |
m |
2/5 |
2/5 |
2/5 |
f |
1/5 |
1/5 |
1/5 |
|
2150 |
m |
0/5 |
0/5 |
0/5 |
f |
0/5 |
0/5 |
0/5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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