Registration Dossier
Registration Dossier
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EC number: 208-634-1 | CAS number: 536-45-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 April 2017 to 16 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 135 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 300 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 9.1 - <= 9.2
- Conclusions:
- Water solubility is 135.0 g/L at 20 ºC and pH 9.1 -9.2 (OECD 105, flask method).
Reference
Results
The concentrations of the different test solutions (supernatants isolated and diluted by factor of 500 mL /0.2 mL, or 2500) were calculated automatically using the equation of the calibration curve. The results are summarised in the table below (duplicate determination).
Incubation time (h) |
Result 1 (mg/500 mL) |
Result 2 (mg/500 mL) |
Average (mg/500 mL) |
24 |
27.1315 |
27.1163 |
27.12 |
48 |
26.9372 |
26.8882 |
26.91 |
72 |
26.9643 |
26.9182 |
26.94 |
With these results, the following value for the water solubility of the test item can be calculated:
Incubation time (hours) |
Water Solubility (g/L) |
Average (g/L) |
24 |
135.6 |
135.0
relative standard deviation:0.41% |
48 |
134.6 |
|
72 |
134.7 |
OECD 105 states, that the values determined for the three test solutions should not deviate by more than 15%. This criterion is fulfilled for this experiment.
Water solubility of the test item Sodium Anisate at 20 °C is 135.0 g/L.
The pH value of the sample solution was 9.1 (9.2, 9.2) after 24 (48, 72) hours of incubation.
The water solubility was determined at 20 °C.
Description of key information
Water solubility is 135.0 g/L at 20 ºC and pH 9.1 -9.2 (OECD 105, flask method).
Key value for chemical safety assessment
- Water solubility:
- 135 g/L
- at the temperature of:
- 20 °C
Additional information
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