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EC number: 274-417-3 | CAS number: 70210-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is Reactive Red 24 carrying a methyl group, while the source chemical is Reactive Red 24:1 carrying an ethyl group.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.
2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Red 24:1 (CAS# 72829-25-5 / EC# 276-911-4)
Target: Reactive Red 24 (CAS# 70210-20-7 / EC# 274-417-3)
3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.12 Auto flammability - Reason / purpose for cross-reference:
- read-across source
- Parameter:
- other: biodegradation measured as BOD vs ThOD
- Value:
- 12
- Sampling time:
- 28 d
- Parameter:
- BOD5
- Value:
- 100 mg O2/g test mat.
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Biodegradation of the substance after 28 days was 12%. The substance is not readily nor inherently biodegradable.
- Executive summary:
A key study was performed to determine the percent biodegradation of the source substance. The inherent biodegradability was determined in a 28 days MITI (II) - test according to OECD TG 302C. The source substance was tested in a concentration of 30 mg/l. The reference substance (Sodium benzoate) was tested in a concentration of 100 mg/l. Based on the results of the study, biodegradation of the test substance after 28 days was 12 %. The structurally related target substance will show similar behaviour.
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- BOD value
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- None
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Details on inoculum:
- None
- Duration of test (contact time):
- 5 d
- Details on study design:
- None
- Preliminary study:
- None
- Test performance:
- None
- Details on results:
- None
- Key result
- Parameter:
- BOD5
- Value:
- 0 mg O2/g test mat.
- Results with reference substance:
- None
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The BOD of FAT 40034 is: 0.0 mg O2/g test mat.
- Executive summary:
The biochemical oxygen demand of FAT 40034 is determined by measuring the dissolved oxygen concentration before and after 5 days incubation at 20 °C in different test concentrations diluted in water saturated with dissolved oxygen that contains a seed of microorganisms. Based on the findings from the study, the BOD5 of FAT 40034 is 0.0 mg O2/g test mat.
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- COD value
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- None
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Specific details on test material used for the study:
- None
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Details on inoculum:
- None
- Duration of test (contact time):
- 5 d
- Details on study design:
- None
- Preliminary study:
- None
- Test performance:
- None
- Details on results:
- None
- Key result
- Parameter:
- COD
- Value:
- 798 mg O2/g test mat.
- Results with reference substance:
- None
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The COD of the test substance FAT 40034 is: 798 mg 02/g.
- Executive summary:
A study was performed to determine the chemical oxygen demand of FAT 40034. Based on the findings from the study, the COD of FAT 40034 is 798 mg02/g
- Endpoint:
- biodegradation in water: inherent biodegradability
- Remarks:
- OECD 302C
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- None
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 C (Inherent Biodegradability: Modified MITI Test (II))
- Deviations:
- yes
- Remarks:
- The test substance was running in duplicate instead in triplicate.
- Principles of method if other than guideline:
- None
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Test medium:
3 ml of each following stock solutions were added per 1 litre distilled water to form the test medium:
Stock solution A:
8,50 g of potassium acid phosphate, 21,75 g of di-potassium hydrogen phosphate, 22,18 g of di-sodium hydrogenphosphate dihydrate and 1,70 g of ammonium chloride were dissolved in distilled water and adjusted to 1 litre. The pH value of this solution was 7,2.
Stock solution B: 22,50 g of magnesium sulfate heptahydrate were dissolved in distilled water and adjusted to 1 litre.
Stock solution C: 36,40 g of calcium chloride dihydrate were dissolved in distilled water and adjusted to 1 litre.
Stock solution D: 0,25 g of ferric chloride hexahydrate were dissolved in distilled water and adjusted to 1 litre. - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Mixture of polyvalent bacteria collected on April 23, 1996 in the aeration tank of a domestic sewage treatment plant, PRO RHENO Basel communal.
- Details on inoculum:
- Mixture of polyvalent bacteria collected on April 23, 1996 in the aeration tank of a domestic sewage treatment plant, PRO RHENO Basel communal. Bacteria concentration: 100 mg/l suspended solids.
- Duration of test (contact time):
- 28 d
- Details on study design:
- Performance of the test:
This test method was based on the following conditions:
- test chemicals as sole organic carbon sources
- no adaptation of micro-organisms to the test chemicals
Tested chemicals were inoculated in the testing vessels with micro-organisms. During the test period, the Biochemical Oxygen Demand was measured continuously by means of a BOD-meter. Biodegradability was calculated on the basis of the theoretical oxygen demand (ThOD) or less satisfactorily COD, if the ThOD could not be calculated. Optionally, primary biodegradation could be determined by analysis of dissolved organic carbon (DOC) at the beginning and the end of the test. - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- None
- Key result
- Parameter:
- other: Biodegradation measured as BOD versus ThOD
- Value:
- 12
- Sampling time:
- 28 d
- Remarks on result:
- other: Standard deviation is not available
- Details on results:
- Test substance:
The biodegradation of FAT 40034/D corrected by the inoculum control and measured as
BOD versus ThOD was: 12% after 28 days
The BOD5 after 5 days was: 100 mg O2/g
Abiotic control:
The abiotic degradation at the end of the test and measured as BOD versus ThOD was: 0 % - Parameter:
- BOD5
- Value:
- 100 mg O2/g test mat.
- Results with reference substance:
- The biodegradation of the reference substance corrected by the inoculum control and measured as BOD versus ThOD was 84 % after 7 days
and was: 94 % after 14 days
and was: 100% after 28 days - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Biodegradation of the test substance after 28 days was 12 %.
- Executive summary:
A key study was performed to determine the percent biodegradation of FAT 40034. An inherent biodegradability of FAT 40034/D was determined in a 28 days MITI (II) - Test according to the OECD Guideline for Testing of Chemicals, No. 302C. The test substance was tested in a concentration of 30 mg/l. The reference substance (Sodium benzoate) was tested in a concentration of 100 mg/l. Based on the results of the study, biodegradation of the test substance after 28 days was 12 %.
Referenceopen allclose all
None
None
None
Description of key information
The substance is a reactive dye and as such the substance should not be considered to be biodegradable at all.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The target substance is a reactive dye and as such the substance should not be considered to be biodegradable at all. The key study was performed according to OECD TG 302B, inherent biodegradation of the source substance after 28 d was 12%, confirming that the substance should not be considered as inherently or readily biodegradable under the conditions of this test. In addition determination of BOD and COD values and calculation of the BOD5/COD quotient resulted in a value of zero. Based on this the read-across source substance is regarded to be not biodegradable at all. Therefore, the target substance is also considered to be not biodegradable what is expected for a reactive dye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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