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Diss Factsheets
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EC number: 947-572-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin irritation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 404), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods. - GLP compliance:
- no
Test material
- Reference substance name:
- methyl 2-methylbenzene-1-sulfonate
- Cas Number:
- 23373-38-8
- Molecular formula:
- C8H10O3S
- IUPAC Name:
- methyl 2-methylbenzene-1-sulfonate
- Reference substance name:
- Methyl toluene-4-sulphonate
- EC Number:
- 201-283-5
- EC Name:
- Methyl toluene-4-sulphonate
- Cas Number:
- 80-48-8
- Molecular formula:
- C8H10O3S
- IUPAC Name:
- methyl 4-methylbenzene-1-sulfonate
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no information available
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data available - Duration of treatment / exposure:
- 1 min., 5 min., 15 min. and 20 hour(s)
- Observation period:
- 14 days
- Number of animals:
- no data available
- Details on study design:
- The backs and ears of very susceptible white rabbits were treated with undiluted test material. After several exposure times the application side was examined after washing (after 1, 5 and 15 minutes exposure; no washing after exposure during 20 hours). The effects observed were described qualitatively.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol concentrated and afterwards with Lutrol diluted to 50 % with water.
- Scoring system: no data, results are described qualitatively
- Examination time points: at the end of exposure
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: qualitative description of effects
- Basis:
- animal:
- Time point:
- other: after 1, 5 and 15 minutes
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: qualitative description of effects
- Basis:
- animal:
- Time point:
- other: 20 hours and 14 days after the end of exposure
- Reversibility:
- other: fully reversible within 14 days.
- Remarks on result:
- other: inflammation followed by degeneration involving only the upper layers of the skin
Applicant's summary and conclusion
- Interpretation of results:
- other: irritant
- Executive summary:
In a study already performed in the 1960s the undiluted test substance was severely irritant to the rabbit´s skin after a 20-hours contact period, as evidenced by skin inflammation with scabs and scales formation which were reversible at the end of the 14-days observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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