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Diss Factsheets
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EC number: 947-572-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.955 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Temp.:
- 20 °C
- pH:
- 1.7
- Remarks on result:
- other: Mean value of two determinations (Flask B and Flask C)
- Details on results:
- By end of the test it was visually observed that in Flask A no undissolved parts of the test item were present anymore whereas in the test solutions of Flask B and Flask C undissolved droplets were still visible. It was therefore assumed that the test item might not be completely stable in aqueous media after 96 hours stirring time (72 h at 30 °C and 24 h at 20 °C).
- Conclusions:
- The water solubility of test substance in demineralized water at 20 °C was 0.955 g/L measured at approx. pH 1.7.
- Executive summary:
The water solubility is determined based on the methods described in the OECD Guideline 105 and EC Guideline A.6. In a preliminary test, the water solubility of the test substance was found to be higher than 0.01 g/L. Therefore the flask method was chosen for the determination of the water solubility. For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and the vessels are kept in the temperature controlled water bath for another 24 h. After phase separation by filtration with a disposable syringe filter and/or centrifugation, respectively, the concentration of the test substance in the aqueous test solutions is determined by HPLC-analysis with UV-detection. By end of the test it was visually observed that in Flask A no undissolved parts of the test substance were present anymore whereas in the test solutions of Flask B and Flask C undissolved droplets were still visible. It was therefore assumed that the test substance might not be completely stable in aqueous media after 96 hours stirring time (72 h at 30 °C and 24 h at 20 °C). The beginning hydrolytic degradation of the test item was indicated as the chromatograms of the aqueous test solutions show an additional peak at approx. 1.3 min – most likely the hydrolysis product of the test substance. The deviation between the single determinations (Flask B and Flask C) was lower than 15 %. The validity criteria of OECD Guideline 105 have therefore been met. The water solubility in demineralized water at 20 °C was 0.955 g/L (pH-value approx. 1.7).
Reference
The beginning hydrolytic degradation of the test item was indicated as the chromatograms of the aqueous test solutions show an additional peak at approx. 1.3 min – most likely the hydrolysis product of the test item.
Description of key information
The water solubility is determined based on the methods described in the OECD Guideline 105 and EC Guideline A.6 by flask method.
For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and the vessels are kept in the temperature controlled water bath for another 24 h.
The water solubility of test substance in demineralized water at 20 °C was determined as 0.955 g/L (pH-value approx. 1.7).
Key value for chemical safety assessment
- Water solubility:
- 0.955 g/L
- at the temperature of:
- 20 °C
Additional information
By end of the test it was visually observed that in Flask A no undissolved parts of the test substance were present anymore whereas in the test solutions of Flask B and Flask C undissolved droplets were still visible. It was therefore assumed that the test substance might not be completely stable in aqueous media after 96 hours stirring time (72 h at 30 °C and 24 h at 20 °C).
The beginning hydrolytic degradation of the test item was indicated as the chromatograms of the aqueous test solutions show an additional peak at approx. 1.3 min – most likely the hydrolysis product of the test item.
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