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Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
internal SOP based on Council Regulations EC No 440/2008, Guideline Part A
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Remarks:
The water solubility of the test item, measured in a preliminary test, was < 10-2 g/L. Therefore, the column elution method was chosen for the determination of the water solubility (column elution method for solubility < 10-2 g/L).
Specific details on test material used for the study:
Purity: 77.6 %
Batch no.: CHC 005
Date of receipt: 2016-08-22
Expiry date: 2021-07-19
Key result
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/100 mL
Temp.:
20 °C
pH:
>= 6.7 - <= 7.3
Remarks on result:
other: Overall mean value
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Mean of plateau values
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Mean of plateau values
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Plateau value 1
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Plateau value 2
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Plateau value 3
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Plateau value 4
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.8 - <= 7.3
Remarks on result:
other: Concentration in column 1, Plateau value 5
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Plateau value 1
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Plateau value 2
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Plateau value 3
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Plateau value 4
Water solubility:
0 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
30.7 other: mg/ 100 mL
Temp.:
20 °C
pH:
>= 6.6 - <= 7
Remarks on result:
other: Concentration in column 2, Plateau value 5
Details on results:
The concentrations of 1,4-Dichloro-5,8-dihydroxyanthraquinone in the fractions were determined by HPLC-MS/MS. Nineteen fractions were collected from column 1 and fourteen fractions from column 2.

Column 1
Mean value: 0.00001313 g/L
Standard deviation: 0.00000095 g/L
Relative standard deviation: 7.2 %

Column 2
Mean value: 0.00001039 g/L
Standard deviation: 0.000000134 g/L
Relative standard deviation: 1.3 %

Difference between both columns: 23 %

The validity criterion (mean of both determinations should not differ by more than 30 %) was met.

Result of the preliminary test: < 0.00004 g/L.

Conclusions:
The water solubility of 1,4-Dichloro-5,8-dihydroxyanthraquinone is stated as: 0.0000118 g/L at 20°C.
Executive summary:

With 1,4-Dichloro-5,8-dihydroxyanthraquinone water solubility by column elution method according to OECD TG 105 was determined. The water solubility is stated as 0.0000118 g/L at 20°C.

The concentrations of 1,4-Dichloro-5,8-dihydroxyanthraquinone in the fractions were determined by HPLC-MS/MS.

Description of key information

With 1,4-Dichloro-5,8-dihydroxyanthraquinone water solubility by column elution method according to OECD TG 105 was determined. The water solubility is stated as 0.0000118 g/L at 20°C.

The concentrations of 1,4-Dichloro-5,8-dihydroxyanthraquinone in the fractions were determined by HPLC-MS/MS.

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information