Registration Dossier
Registration Dossier
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EC number: 231-128-7 | CAS number: 7440-19-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- The surface of samarium metal oxidises on contact with air to form an outer layer of samarium oxide. It is therefore considered appropriate to read across information from samarium oxide to the metal where testing on the metal is not technically possible.
Cross-reference
- Reason / purpose for cross-reference:
- other: read-across target
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted on read-across material
- Justification for type of information:
- The surface of samarium metal oxidises on contact with air to form an outer layer of samarium oxide. It is therefore considered appropriate to read across information from samarium oxide to the metal where testing on the metal is not technically possible.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- other: Draize score
- Remarks:
- (unwashed eyes)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.4
- Reversibility:
- not specified
- Irritation parameter:
- other: Draize score
- Remarks:
- (washed eyes)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.1
- Reversibility:
- not specified
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Samarium Oxide.
- Author:
- Lambert, C.E., Barnum, E.C. and R. Shapiro
- Year:
- 1 990
- Bibliographic source:
- Acute Toxicological Evaluation of Samarium Oxide (1990), UNOCAL, 1201 West 5th Street, Los Angeles, CA 90051.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 0.1 g dose was applied to the left eye of six rabbits (New Zealand Albino). Three of the treated eyes were rinsed with saline 30 seconds post-installation. Eyes were examined at 24, 48 and 72 hours by the method of Draize.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Samarium (III) oxide
- EC Number:
- 235-043-6
- EC Name:
- Samarium (III) oxide
- Cas Number:
- 12060-58-1
- Molecular formula:
- O3Sm2
- IUPAC Name:
- Samarium (III) oxide
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 g - Observation period (in vivo):
- Eyes were examined at 24, 48 and 72 hours.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
Three of the treated eyes were rinsed with saline 30 seconds post-installation.
SCORING SYSTEM:
Eyes were evaluated according to the method of Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Draize score
- Remarks:
- (unwashed eyes)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.4
- Reversibility:
- not specified
- Irritation parameter:
- other: Draize score
- Remarks:
- (washed eyes)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.1
- Reversibility:
- not specified
Any other information on results incl. tables
Draize scores:
- Unwashed (3 rabbit mean) 24h 5.3 48h 2.0 72h 0.0
- Washed (3 rabbit mean) 24h 5.3 48h 3.3 72h 0.7
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Samarium oxide was concluded to be minimally irritating to both the unwashed and washed eye under the conditions of the study.
- Executive summary:
The eye irritation potential of the substance samarium oxide was evaluated.
During the study, a 0.1 g dose was applied to the left eye of six rabbits (New Zealand Albino). Three of the treated eyes were rinsed with saline 30 seconds post-installation. Eyes were examined at 24, 48 and 72 hours by the method of Draize.
The mean Draize scores of the three rabbits with unwashed treatment eyes were 5.3, 2.0 and 0.0 at 24, 48 and 72 hours, respectively.
The mean Draize scored of the three rabbits with washed treatment eyes were 5.3, 3.3 and 0.7 at 24, 48 and 72 hours, respectively.
Samarium oxide was concluded to be minimally irritating to both the unwashed and washed eye under the conditions of the study.
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