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EC number: 233-143-4 | CAS number: 10043-84-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INVENTORY MULTI-TIERED ASSESSMENT AND PRIORITISATION (IMAP) - NICNAS
- Author:
- National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
- Year:
- 2 018
- Bibliographic source:
- INVENTORY MULTI-TIERED ASSESSMENT AND PRIORITISATION (IMAP) - NICNAS, 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the eye irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Manganese bis(dihydrogen phosphate)
- EC Number:
- 242-520-2
- EC Name:
- Manganese bis(dihydrogen phosphate)
- Cas Number:
- 18718-07-5
- Molecular formula:
- H3O4P.1/2Mn
- IUPAC Name:
- Manganese bis(dihydrogen phosphate)
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Manganese bis(dihydrogen phosphate)
Molecular Formula:H3O4P.1/2Mn
Molecular Weight: 249 g/mol
Substance Type: Inorganic
Physical State: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- sex: female
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 24, 48 and 72 hour time-points till 10 days
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 3 female
- Details on study design:
- No data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- No data available
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- chemosis was not fully reversed within seven days in one rabbit; conjunctival redness was fully reversible within 10 days; corneal opacity was not fully reversed within 72 hours in one rabbit
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The average score for corneal opacity was 0.33/4 for all animals over the 24, 48 and 72 hour time-points, it was not fully reversed within 72 hours in one rabbit. There was no iritis in any rabbit over the duration of the study. The average score for conjunctival redness was 3/3 for all animals over the 24, 48 and 72 hour time-points, but this was fully reversible within 10 days. The average score for chemosis was 3/4 for all animals over the 24, 48 and 72 hour time-points and chemosis was not fully reversed within seven days in one rabbit.
Since the most of the effects were not reversible by 10 days, the test chemical can be considered to be irritating to eyes. - Executive summary:
The ocular irritation potential of the test chemical was assessed in rabbits according to OECD 405 Guidelines. 100 mg of undiluted test chemical was instilled in the eyes of 3 female New Zealand White rabbits and observed for signs of irritation till 10 days.It was observed that corneal opacity was minimal (average 0.33/4 for all animals over the 24, 48 and 72 hour time-points), but that it was not fully reversed within 72 hours in one rabbit. There was no iritis in any rabbit over the duration of the study. The average score for conjunctival redness was 3/3 for all animals over the 24, 48 and 72 hour time-points, but this was fully reversible within 10 days. The average score for chemosis was 3/4 for all animals over the 24, 48 and 72 hour time-points and chemosis was not fully reversed within seven days in one rabbit.
Since the most of the effects were not reversible by 10 days, the test chemical can be considered to be irritating to eyes.
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