Registration Dossier
Registration Dossier
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EC number: 601-639-3 | CAS number: 119851-28-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone
- EC Number:
- 601-639-3
- Cas Number:
- 119851-28-4
- Molecular formula:
- C14H10Cl2O2
- IUPAC Name:
- 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rat (Tif: RAI f (SPF) hybrids of RII/1 x RII/2
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5150 +- 127 mg/m3
- No. of animals per sex per dose:
- 5 males and 5 females dose group and a control group of equal size
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 5 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 5 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute aerosol inhalation toxicity of the TS was determined to be: LC50 (m/f) >5100 mg/m3 air
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