Registration Dossier
Registration Dossier
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EC number: 601-639-3 | CAS number: 119851-28-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone
- EC Number:
- 601-639-3
- Cas Number:
- 119851-28-4
- Molecular formula:
- C14H10Cl2O2
- IUPAC Name:
- 1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: gauze patches moistened with distilled water containing 0.5 % carboxymethylcellulose and 0.1 % polysorbate 80
- Controls:
- other: A control gauze patch was applied to the contralateral flank
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 males
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- control flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- test flank
- Time point:
- other: 24 - 72 hrs (mean)
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The TS has no primary skin irritation potency in albino rabbits.
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