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The test substance did not induce any signs of systemic toxicity in a 90 -day repeated dose toxicity study according to OECD 408 (BASF SE/Evonik, 2014). The weight effects observed in males in the 28 -day repeatde dose toxicity study according to OECD 407 were not confirmed, indicating that these gender (male)-specific effects were incidental and do not need to be considered for risk assessment. The only effects observed with the test substance were related to male-rat specific effects (alpha-2µ), were without dose-dependency or without histological correlate. Hence, the test substance can be regarded as being of low general toxicity for human health.