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EC number: 203-951-1 | CAS number: 112-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was not conducted in accordance with GLP but sufficient data is available for the interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C6H13OCH2CH2OH
- IUPAC Name:
- 2-hexyloxyethanol
- Details on test material:
- - Name of test material (as cited in study report): Hexyl CELLOSOLVE (Ethylene glycol monohexyl ether)
- Physical state: Clear, non-viscous liquid
- Lot/batch No.: S074565
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified in the report
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Clipped intact skin of the trunk
- Type of wrap if used: Vetrap bandaging tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: 24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 4 ml/kg, 2 ml/kg, 1 ml/kg and 0.5 ml/kg
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals observed daily and body weights taken weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology - Statistics:
- Means and standard deviations of animal body weights were calculated for descriptive purposes.
Results and discussion
- Preliminary study:
- none
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.81 mL/kg bw
- 95% CL:
- 0.59 - 1.12
- Remarks on result:
- other: calculated (757.35 mg/kg)
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 0.93 mL/kg bw
- 95% CL:
- 0.63 - 1.38
- Remarks on result:
- other: calculated (869.55 mg/kg)
- Mortality:
- Male: 4 ml/kg 5/5 , 2 ml/kg 5/5 , 1 ml/kg 4/5 and 0.5 ml/kg 0/5
Female: 4 ml/kg 5/5 , 2 ml/kg 5/5 , 1 ml/kg 3/5 and 0.5 ml/kg 0/5
Time to death ranged from one to 3 days. Survivors recovered at 2 to 4 days. - Clinical signs:
- other: Local dermal effects included erythema, edema, ecchymosis, necrosis, desquamation, scabs and ulceration. A comatose appearance, red perinasal discharge, sluggishness and an unsteady gait were among the signs of toxicity observed.
- Gross pathology:
- Gross pathologic findings included mottled and pink to red lungs, red thymuses, a few red tracheas and dorsal alopecia.
- Other findings:
- None
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- By the percutaneous route, the LD50 for male rabbits was 0.81 ml/kg (calculated 757.35 mg/kg). The LD50 for females was 0.93 ml/kg (calculated 869.55 mg/kg)
- Executive summary:
Ethylene glycol mono hexyl ether was evaluated for acute dermal test in rabbits. New Zealand White rabbits, weighing between 2.0 and 3.0 kg, were subjected to 24 hours of contact with the test material which was retained under impervious sheeting on the clipped, intact skin of the trunk. As necessary for larger doses, gauze was wrapped around the trunk over the sample to prevent leakage. Vetrap Bandaging Tape was wrapped over the impervious sheeting and the animal was returned to its cage for the contact period. Doses were varied by adjusting the volume or weight of the test material. Solids dosed as powders and were moistened with a sufficient amount of water or other suitable vehicle to form a paste. After the contact period, excess fluid was removed to diminish ingestion. Observations for skin reaction are made at one hour, 7 days and 14 days after the contact period. Five male and 5 females were included on each level used for the LD50 calculation.
By the percutaneous route, the LD50 for male rabbits was 0.81 ml/kg. The D50 for females was 0.93 ml/kg. Local dermal effects included erythema, edema, ecchymosis, necrosis, desquamation, scabs and ulceration.
A comatose appearance, red perinasal discharge, sluggishness and an unsteady gait were among the signs of toxicity observed. Time to death ranged from one to 3 days. Survivors recovered at 2 to 4 days. Gross pathologic findings included mottled and pink to red lungs, red thymuses, a few red tracheas and dorsal alopecia.
By the percutaneous route, the LD50 for male rabbits was 0.81 ml/kg (calculated 757.35 mg/kg). The LD50 for females was 0.93 ml/kg (calculated 869.55 mg/kg)
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