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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Aug - 08 Sep 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 02 Oct 2012
- Deviations:
- yes
- Remarks:
- (no systemic analgesic and topical anesthesia used)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bayrisches Landesamt für Arbeitsschutz, Arbeitsmedizin und Sicherheitstechnik, München, Germany
Test material
- Reference substance name:
- Quinolin-8-ol
- EC Number:
- 205-711-1
- EC Name:
- Quinolin-8-ol
- Cas Number:
- 148-24-3
- Molecular formula:
- C9H7NO
- IUPAC Name:
- quinolin-8-ol
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HdIf:NZW
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen, Germany
- Weight at study initiation: > 2.0 kg weight
- Housing: housed in ABS - plastic rabbit cages, floor 4200 cm²
- Diet: Altromin 2123, ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 55 ± 10
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 g - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- Animal no.1: 20 days; Reading time points: 1, 24, 48 and 72 h and daily from Day 4 - Day 20
Animal no. 2 and 3: 168 h; Reading time points: 1, 24, 48 and 72 h and daily from Day 4 - Day 7 - Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days in 2 animals, within 4 days in 1 animal
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: within 3 days in 1 animal, within 2 days in 2 animals
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 20 days in 1 animal, no effect in 2 animals
- Irritant / corrosive response data:
- Instillation of the test substance into the eyes of rabbits produced signs of irritation in all animals. In detail, redness and chemosis of the conjunctivae were observed in all test animals. Those effcets were fully reversible latest within 168 or 72 hours, respectively. Furthermore, 1/3 animals showed corneal opacity which was not reversible until the end of the observation period (20 days). In the 2 remaining animals, no effects on the cornea were determined. No effects on the iris were observed in any test animal.
- Other effects:
- Body weight evolution appeared normal.
Any other information on results incl. tables
Table 1 Results of eye irritation
Rabbit # | Time [h] | conjunctivae | iris | cornea | |
redness | swelling | ||||
1 | 1 | 2 | 2 | 0 | 1 |
24 | 1 | 1 | 0 | 1 | |
48 | 1 | 0 | 0 | 1 | |
72 | 1 | 0 | 0 | 1 | |
average | 1,0 | 0,3 | 0,0 | 1,0 | |
2 | 1 | 2 | 2 | 0 | 0 |
24 | 2 | 1 | 0 | 0 | |
48 | 1 | 0 | 0 | 0 | |
72 | 1 | 0 | 0 | 0 | |
average | 1,3 | 0,3 | 0,0 | 0,0 | |
3 | 1 | 2 | 2 | 0 | 0 |
24 | 2 | 1 | 0 | 0 | |
48 | 1 | 1 | 0 | 0 | |
72 | 1 | 0 | 0 | 0 | |
average | 1,3 | 0,7 | 0,0 | 0,0 | |
Time [h] | conjunctivae | iris | cornea | ||
redness | swelling | ||||
average score |
1 | 2,00 | 2,00 | 0,00 | 0,33 |
24 | 1,67 | 1,00 | 0,00 | 0,33 | |
48 | 1,00 | 0,33 | 0,00 | 0,33 | |
72 | 1,00 | 0,00 | 0,00 | 0,33 | |
24+48+72 | 1,2 | 0,4 | 0,0 | 0,3 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Cat. 1, H318
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