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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (rabbit): not irritating
Eye irritation (rabbit): corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 - 09 Aug 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 28 Jul 2015
- Deviations:
- yes
- Remarks:
- (all 3 animals were tested in parallel, no initiating and confirmatory test performed)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bayrisches Landesamt für Arbeitsschutz, Arbeitsmedizin und Sicherheitstechnik, München, Germany
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HsdIf:NZW
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen, Germany
- Weight at study initiation: at least 2 kg bw
- Housing: housed in ABS - plastic rabbit cages, floor 4200 cm²
- Diet: Altromin 2123, ad libitum
- Water: tap water, ad libitum)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 55 ± 10
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
Reading time points: 1, 24, 48 and 72 h - Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² on the dorsal area of the trunk
- Type of wrap if used: The test substance was applied to a gauze patch which was applied to the skin and fixed with a non-irritating, semi-occlusive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: Residual test material was removed with tap water
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS
Reading time points: 1, 24, 48 and 72 h
SCORING SYSTEM:
- Method of calculation: Draize scoring system - Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test item showed neither irritant nor corrosive effects on the intact skin of 3 rabbits after a contact time of 4 h.
- Other effects:
- Body weight evolution appeared normal.
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation(EC) No. 1272/2008
- Conclusions:
- CLP: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Aug - 08 Sep 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 02 Oct 2012
- Deviations:
- yes
- Remarks:
- (no systemic analgesic and topical anesthesia used)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bayrisches Landesamt für Arbeitsschutz, Arbeitsmedizin und Sicherheitstechnik, München, Germany
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HdIf:NZW
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Winkelmann GmbH, Borchen, Germany
- Weight at study initiation: > 2.0 kg weight
- Housing: housed in ABS - plastic rabbit cages, floor 4200 cm²
- Diet: Altromin 2123, ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 55 ± 10
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 g - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- Animal no.1: 20 days; Reading time points: 1, 24, 48 and 72 h and daily from Day 4 - Day 20
Animal no. 2 and 3: 168 h; Reading time points: 1, 24, 48 and 72 h and daily from Day 4 - Day 7 - Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days in 2 animals, within 4 days in 1 animal
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: within 3 days in 1 animal, within 2 days in 2 animals
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 20 days in 1 animal, no effect in 2 animals
- Irritant / corrosive response data:
- Instillation of the test substance into the eyes of rabbits produced signs of irritation in all animals. In detail, redness and chemosis of the conjunctivae were observed in all test animals. Those effcets were fully reversible latest within 168 or 72 hours, respectively. Furthermore, 1/3 animals showed corneal opacity which was not reversible until the end of the observation period (20 days). In the 2 remaining animals, no effects on the cornea were determined. No effects on the iris were observed in any test animal.
- Other effects:
- Body weight evolution appeared normal.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Cat. 1, H318
Reference
Table 1 Results of eye irritation
Rabbit # | Time [h] | conjunctivae | iris | cornea | |
redness | swelling | ||||
1 | 1 | 2 | 2 | 0 | 1 |
24 | 1 | 1 | 0 | 1 | |
48 | 1 | 0 | 0 | 1 | |
72 | 1 | 0 | 0 | 1 | |
average | 1,0 | 0,3 | 0,0 | 1,0 | |
2 | 1 | 2 | 2 | 0 | 0 |
24 | 2 | 1 | 0 | 0 | |
48 | 1 | 0 | 0 | 0 | |
72 | 1 | 0 | 0 | 0 | |
average | 1,3 | 0,3 | 0,0 | 0,0 | |
3 | 1 | 2 | 2 | 0 | 0 |
24 | 2 | 1 | 0 | 0 | |
48 | 1 | 1 | 0 | 0 | |
72 | 1 | 0 | 0 | 0 | |
average | 1,3 | 0,7 | 0,0 | 0,0 | |
Time [h] | conjunctivae | iris | cornea | ||
redness | swelling | ||||
average score |
1 | 2,00 | 2,00 | 0,00 | 0,33 |
24 | 1,67 | 1,00 | 0,00 | 0,33 | |
48 | 1,00 | 0,33 | 0,00 | 0,33 | |
72 | 1,00 | 0,00 | 0,00 | 0,33 | |
24+48+72 | 1,2 | 0,4 | 0,0 | 0,3 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritancy potential of quinolin-8-ol (CAS 148-24-3) was determined in a skin irritation study in white rabbits (NZW) performed according to GLP and OECD TG 404 (reference 7.3.1-1). The test substance was topically applied to the skin of three rabbits for 4 h. Local reactions were scored at 1, 24, 48 and 72 h. No local reactions were observed (meanerythema and edema scores of 0.0 calculated as mean for all animals over 24, 48 and 72 h). Based on the results of the conducted study,quinolin-8-oldid not exhibit irritating properties towards the skin.
Eye irritation
To evaluate the irritation potential towards the eyes, 0.1 g quinolin-8-ol (CAS 148-24-3) was instilled into the eyes of three white rabbits (NZW) similar to OECD TG 405 and GLP criteria (reference 7.3.2-1). The reactions were observed 1 h after substance application and daily from Day 1 up to Day 20. Instillation of the test substance into the eyes produced signs of irritation in all animals. In detail, redness and chemosis of the conjunctivae were observed in all test animals. Those effects were fully reversible latest within 168 hours, respectively. Furthermore, 1/3 animals showed corneal opacity which was not reversible until the end of the observation period (20 days). In the 2 remaining animals, no effects on the cornea were determined. No effects on the iris were observed in any test animal. Based on the irreversible corneal lesion observed in 1/3 animals, quinolin-8-ol is considered as corrosive to the eyes.
Justification for classification or non-classification
Based on the available data on skin irritation, quinolin-8-ol does not meet the classification criteria for skin irritation according to Regulation (EC) 1272/2008. The available data on eye irritation with quinolin-8-ol (CAS 148-24-3) meet the criteria for classification as Eye Dam. Cat. 1 (H318) according to Regulation (EC) 1272/2008.
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