Cyclohexyl phenyl ketone

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From Nov. 17, 1980 to Dec. 1, 1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study without detailed documentation.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

Concentration applied not reported.

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: EPA 163.81-5 Vol. 43 No. 163, August 22, 1978

Deviations:

not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohexyl phenyl ketone

EC Number:

211-923-5

EC Name:

Cyclohexyl phenyl ketone

Cas Number:

712-50-5

Molecular formula:

C13H16O

IUPAC Name:

cyclohexyl(phenyl)methanone

Details on test material:

- Name of test material (as cited in study report): TK 12828
- Batch No.; 1
- Physical state: paste

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Housing: individually in metal cages
- Diet (e.g. ad libitum): ad libitum standard rabbit food NAFAG No. 814 Gossau, SG
- Water (e.g. ad libitum): ad libitum tap water
- Acclimation period: 4 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 1
- Photoperiod (hrs dark / hrs light): 10/14

IN-LIFE DATES: From: Novemeber 17, 1980 to Novemeber 23, 1980

Test system

Type of coverage:

occlusive

Preparation of test site:

other: Shaved and one side was abraded.

Vehicle:

other: Not clear whether material is inherently a paste or has been formed into a paste

Controls:

not required

Amount / concentration applied:

0.5 g of test material applied.

Duration of treatment / exposure:

Dressings were removed after 24 hours.

Observation period:

7 days.

Number of animals:

3 males and 3 females.

Details on study design:

Entire back and flank of rabbits was shaved before treatment, and then shaven skin on one side of the animal was abraded. Gauze patches of 2.5 X 2 .5cm with 0.5 g of the test material was applied to the abraded and intact skin. The patches were covered with an impermeable material and fastened to the body with adhesive tape. The skin reaction was appraised upon removal and during an observation period of 7 days on the basis of an evaluation scheme.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 72 hour

Score:

0.4

Max. score:

8

Reversibility:

no data

Remarks on result:

other: 0.2 + 1.0 + 0 +0.4 = 1.6/4 = 0.4

Irritant / corrosive response data:

Cyclohexylphenylketone was reported to cause minimal irritation when applied to intact and abraded rabbit skin.

Applicant's summary and conclusion

Interpretation of results:

other: Not Classified

Remarks:

Criteria used for interpretation of results: OECD GHS