Registration Dossier
Registration Dossier
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EC number: 231-596-2 | CAS number: 7647-10-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Palladium chloride - A potent sensitizer in the guinea pig
- Author:
- Wahlberg JE and Boman A
- Year:
- 1 990
- Bibliographic source:
- Am J Contact Dermatitis 1, 112-113
Materials and methods
- Principles of method if other than guideline:
- Guinea-pig maximisation test.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study completed in 1990.
Test material
- Reference substance name:
- Palladium dichloride
- EC Number:
- 231-596-2
- EC Name:
- Palladium dichloride
- Cas Number:
- 7647-10-1
- Molecular formula:
- Cl2Pd
- IUPAC Name:
- palladium dichloride
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Not specified.
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- 0.03 and 2.5%
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: Saline
- Concentration / amount:
- 0.63 - 1.25%
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- Not specified.
- Details on study design:
- GPMT
pretreatment: FCA
induction: intra- and epidermal (0.03 and 2.5% in water)
challenge: epidermal (0.63-1.25% in saline) - Challenge controls:
- Not specified.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Palladium dichloride was a potent skin sensitiser in a GPMT.
- Executive summary:
The skin sensitising potential of palladium dichloride was investigated in a guinea pig maximisation test (GPMT). Animals were induced with test material (0.03 and 2.5 % in water) by the intradermal and epidermal routes, respectively, following pretreatment with Freund's complete adjuvant. Epidermal challenge (0.63 -1.25% in saline) indicated that palladium dichloride was a potent skin sensitiser in the GPMT.
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