Registration Dossier
Registration Dossier
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EC number: 200-346-4 | CAS number: 57-68-1
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototrasformation
As reported in the summary of environmental fate and exposure in HSDB Report of Sulfamethazine (synonym of Sulfadimidine) by Scientific Review Committee, if released to air the substance will exist solely in the particulate phase in the atmosphere. In fact, estimated vapour pressure for Sulfadimidine is in the order of magnitude of 10^-9 mmHg
Sulfadimidine absorbs light at wavelengths > 290 nm (UV max = 297 nm) and therefore may be susceptible to direct photolysis by sunlight.
Hydrolisis
As reported in the summary of environmental fate and exposure in HSDB Report of Sulfamethazine (synonym of Sulfadimidine) by Scientific Review Committee, for this substance hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions.
Biodegradation
Sulfadimidine is predicted no ready-biodegradable by BIOWIN v.4.10.
Some data regarding biodegradation with activated sludge and biodegradation in the soil are reported in HSDB Report of Sulfamethazine (synonym of Sulfadimidine): Sulfadimidine was completely degraded within 20 days in activated sludge systems, indicating that this substance may undergo biodegradation in soil (ref. Ingerslev et all, Environ Toxicol Chem 19: 2467-73, 2000). However, less than 1% degradation after 64 days in loamy sand and clay silt suggests that biodegradation will be slow in some soils (ref. Thiele-Bruhn S; J Plant Nutr Soil Sci 166: 145-167, 2003).
Bioaccumulation
Bioaccumulation: aquatic
As reported in the summary of environmental fate and exposure in HSDB Report of Sulfamethazine (synonym of Sulfadimidine) by Scientific Review Committee low potential of bioconcentration in aquatic organism is expected for this substance based on estimated BCF of 0.8. A low BCF for Sulfadimidine is predicted also by BCFBAF v.3.01 (log BCF = 0.5; BCF = 3.162 l/kg wet-wt). As reported in the CLP Regulation (EC n.1272/2008) a BCF ≥ 500 is indicative of the potential to bioconcentrate for classification purposes and so BCF minor than 500 for Sulfadimidine is of no concern.
Bioaccumulation: terrestrial
No data available
Transport and distribution
Adsorption/Desorption
As reported in the summary of environmental fate and exposure in HSDB Report of Sulfamethazine (synonym of Sulfadimidine) by Scientific Review Committee, Koc values ranging from 49 to 208 (many references: Thiele-Bruhn S et all, Arch Environ Contam Toxicol 47: 31-39, 2004; Boxall et all, Rev Environ Contam Toxicol 180: 1-91, 2004; Tolls, Environ Sci Technol 35: 3397-406, 2001; Thiele-Bruhn, J Plant Nutr Soil Sci. 166: 145-167, 2003 )indicate that Sulfadimidine is not expected to adsorb to suspended solids and sediment. A low Koc for Sulfadimidine is predicted also by KOCWIN v.2.00 (Koc =191.3 MCI Method equivalent to log Koc= 2.282).
Column 2 of REACH Annexes VIII and IX provides the following exemptions: "The study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient)"
The Sulfadimidine has got log Kow = 0.19 which can be considered of no concern.
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