Registration Dossier
Registration Dossier
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EC number: 221-916-9 | CAS number: 3279-27-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity of o-tert-amylphenol was estimated using a QSAR model. The 21 day ChV was 0.240 mg/L and the calculated NOEC was 0.170 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.17 mg/L
Additional information
No reliable experimental long-term toxicity studies with aquatic invertebrates are available for o-tert-amylphenol. However reliable (Klimisch 2) modeled data are available and included in the dossier. Additionally, a reliable chronic toxicity study with aquatic invertebrates with the structural analogue o-sec-butylphenol has been included for supporting evidence.
Sasol (2016) provided reliable (Klimisch 2) data for o-tert-amylphenol using the QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to aquatic invertebrates. The ECOSAR model estimates aquatic toxicity based on the structural similarity to chemicals for which aquatic studies are available. In addition, the log Kow and molecular weight of o-tert-amylphenol are within the criteria (max log Kow = 7 for acute, 8 for chronic and max molecular weight = 1000) and domain of the model. The measured log Kow of 4.0 was used in the model. Model results indicate a 21 day chronic value (the geometric mean of the NOEC and LOEC) to be 0.240 mg/L using the baseline toxicity equation. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC is 0.170 mg/L.
Japan MOE (1999) conducted a reliable (Klimisch 1) GLP compliant long-term toxicity test following OECD 211 methods on the read across substance o-sec-butylphenol. Daphnia magna were exposed to measured concentrations of 0.0032, 0.01, 0.032, 0.1, 0.32, 1.0, and 3.2 mg/L of o-sec-butylphenol. The 21-day NOEC based on reproduction was 0.32 mg/L.
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