Registration Dossier
Registration Dossier
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EC number: 221-916-9 | CAS number: 3279-27-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
CERI Japan (2008) provided a measured BCF value for read across substance o-tert-butylphenol of 78 for the common carp.
Key value for chemical safety assessment
- BCF (aquatic species):
- 78 L/kg ww
Additional information
Reliable measured and modeled BCF data for o-tert-amylphenol and its structural analogues o-tert-butylphenol and o-sec-butylphenol are available and included in the dossier.
The Chemical Evaluation and Research Institute Japan (2008) conducted a reliable BCF study (Klimisch 2) according to the OECD 305 guideline. The common carp, Cyprinus carpio, were exposed to the structural analogue o-tert-butylphenol where the uptake, tissue distribution and elimination of the test substance in freshwater exposure was investigated. Fish were exposed to measured concentrations of the test substance at 20 ug/L and 2 ug/L in a flow-through system for 28 days. The time of plateau was 15 days and the BCF was based on steady state. The measured BCF for the 20 ug/L exposure was 62 and the BCF for the 2 ug/L exposure was 78.
The Chemical Inspection and Testing Institute (2000) also conducted a reliable (Klimisch 2) BCF study following the OECD 305 guideline on the read across substance o-sec-butylphenol. Two-year old common carp, Cyprinus carpio, were exposed to measured concentrations of 0.001 and 0.10 mg/L in a flow-through system for 28 days. Study results indicated that the BCF for fish was 16 for the 0.10 mg/L concentration and 27 for the 0.001 mg/L concentration.
These measured BCF values are supported by calculated BCF and BAF values for o-tert-amylphenol. BCF values were calculated using the BCFBAF v3.01 module embedded within the EPISuite v4.11 computer model. The calculated BCF (regression-based model) was 121 L/kg wet-wt., while the BAF (Arnot-Gobas upper trophic) was 253 L/kg wet-wt.
Reliable measured and modeled BCF data for o-tert-amylphenol and its structural analogues o-tert-butylphenol and o-sec-butylphenol are available and included in the dossier. Chemical Evaluation and Research Institute Japan (2008) provide a measured BCF value of 78 for the common carp exposed to the read across substance o-tert-butylphenol. Consequently, this value will be taken for the aquatic bioaccumulation in aquatic organisms endpoint.
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