Registration Dossier
Registration Dossier
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EC number: 229-912-9 | CAS number: 6834-92-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publication giving sufficient detail for evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- The solution and excretion of|silica.
- Author:
- King, E. J. and McGeorge, M.
- Year:
- 1 938
- Bibliographic source:
- Biochem. J. 32, 426-433
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- The excretion of silica (SiO2) in urine after oral or inhalative administration of silicate to cats was studied.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium metasilicate
- EC Number:
- 229-912-9
- EC Name:
- Disodium metasilicate
- Cas Number:
- 6834-92-0
- Molecular formula:
- H2O3Si.2Na Soluble Silicates Category
- IUPAC Name:
- disodium oxosilanediolate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- cat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral and inhalation
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Administration of silicic acid freshly precipitated from a sodium metasilicate solution (corresponding to 5 g SiO2) lead to markedly increased silica excretion in the urine as compared to the control. The urinary silica excretion returned to the normal level of excretion within 3 days. A fog of 2% sodium metasilicate solution carefully neutralized with hydrochloric acid to avoid precipitation of silicic acid was administered to cats by means of an atomizer blowing into a rubber mask attached to the cat's nostrils. A marked increase in the silica (SiO2) of the urine was observed which persisted for several days after the experiment was concluded. The dust of air-dried and finely ground amorphous silica obtained from a sodium metasilicate solution by acid precipitation was adminstered for 6 hours to the nostrils of cats using a rubber mask. A big transitory increase in urinary silica excretion was observed.
Applicant's summary and conclusion
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