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EC number: 246-770-3 | CAS number: 25265-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Oxydipropanol
- EC Number:
- 246-770-3
- EC Name:
- Oxydipropanol
- Cas Number:
- 25265-71-8
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 1,1-Oxydi-2-Propanol
- Details on test material:
- - Name of test material (as cited in study report): dipropylene glycol
- Physical state: clear viscous liquid
- Analytical purity: 100%
- Lot/batch No.: TB41213-04-2
- Storage condition of test material: in the original container (blue metal can), at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: bred in the laboratory colony (Branchville)
- Age at study initiation: males approximately 17 weeks of age, females approximately 16 weeks of age.
- Weight at study initiation: males 2.70 to 2.95 kilograms, females 2.50 to 2.60 kg.
- Housing: the animals were housed singly in wire cages in the study room
- Diet (e.g. ad libitum): Blue Seal Rabbit Feed, ID #1679 JJA, supplemented with oats if necessary
- Water (e.g. ad libitum): potable municpal water (ad libitum)
- Acclimation period: acclimated to the study room for 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68-74ºF
- Humidity (%): 35-65
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hours on/12 hours off cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was applied uniformly at the required dose to the shaved intact skin in an area forming a band on the dorsal and lateral trunk that approximated 10% of the body surface of the rabbit as nearly as the dose allowed. The test substance was held in contact with the skin by a gauze pad held in place with hypo-allergenic tape. The entire trunk of the rabbit was then wrapped with no-irritating perforated plastic sheeting secured at each end with masking tape in order to prevent displacement or ingestion of the test substance.
- Duration of exposure:
- 24 hours
- Doses:
- 5.01 g/kg body weight
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observation and scoring: 30 to 60 minutes after cleaning the skin at approximately 24 hours, the local reaction was recorded; erythema and edema were scored using the variation of the method of Draize. Readings were also made on days 3, 7, 14 and at other times if major changes were observed. The animals were observed for mortality and pharmacotoxic signs frequently on the day of dosing and once daily for the remainder of the 14 day observation period. This included time of death, or nature, onset, severity and duration of all gross visible toxic or pharmacologic effects, e.g. changes in skin and fur, eye and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somato-motor activity and behavioral pattern. In addition, animals were checked for mortality each afternoon (except weekends and holidays).
- Body weights: were detemined on the day of dosing, weekly thereafter and at sacrifice.
- Necropsy of survivors performed: yes. Animals that survived the 14 day observation period were sacrificed and a gross necropsy was performed. Any animals found dead during the study would have undergon necropsy immediately. Gross necropsy consisted of examination of the carcass (including the test site), the visceral organs in the thorax and abdomen, and examination of the reproductive organs. - Statistics:
- None used
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Mortality:
- The were no deaths
- Clinical signs:
- other: Cageside observation of the rabbits during the study did not reveal any overt signs of systemic pharmacologic or toxic effects. Approximately three quarters of an hour after removal of the wraps and cleaning the skin there was very slight irritation char
- Gross pathology:
- At necropsy all organs and tissues examend grossly appeared normal and there were no pathognomonic signes. The shaved skin in the area of application of the test substance appeared normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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