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EC number: 200-580-7 | CAS number: 64-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 4-18 April 1995
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study report has not been received and therefore cannot be reviewed and evaluated in full.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- Principles of method if other than guideline:
- No data reported.
- GLP compliance:
- yes
Test material
- Reference substance name:
- TEM 123 (CEL 350 20 H SL)
- IUPAC Name:
- TEM 123 (CEL 350 20 H SL)
- Details on test material:
- 10% acetic acid. Liquid. Water soluble concentrate (ready for use). Batch number: 0395. Substance was stable under test conditions.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data reported.
Sampling and analysis
- Analytical monitoring:
- not specified
- Details on sampling:
- Assessment of toxicity effects to earthworms were carried out on days 7 and 14.
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- Artificial soil was prepared using: 10% Sphagnum peat, 20% Kaolin clay, 69% industiral sand, 1% calcium, deionised water (to water content of 25%).
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Species: Eisenia foetida (Savigny) and Eisenia fetida andrei (Bouche) - 1826 (Earthworms). At test initiation: adult worms, 7 months old. Weight at test initiation: 3378-3660 mg/ 10 earthworms. Source: worms were taken from a healthy stock within the test facility, which were kept under laboratory conditions. Acclimitisation: 24 ours in moist artificial soil.
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Post exposure observation period:
- No data reported.
Test conditions
- Test temperature:
- 20 +/- 2˚C
- pH:
- No data reported.
- Moisture:
- 25%
- Details on test conditions:
- Tests were carried out in 1L glass vessels with lids in a climate controlled chamber. The test chambers were continually exposed to light at 400-800 lux (daylight). Number of worms per vessel: 10. Number of replicates: 4.
- Nominal and measured concentrations:
- Nominal concentrations: 0, 2.86, 28.6, 71.4, 143, 286 mL/kg dry weight. These nominal concentrations correspond to field doses of: 0, 2000, 20000, 50000, 100000, 200000 L/ha.
- Reference substance (positive control):
- yes
- Remarks:
- 100% 2-chloracetamide
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 28.6 other: mL/kg d.w.
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 2914 mg as/kg d.w.
- Duration:
- 14 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 71.4 other: mL/kg d.w.
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 7286 mg as/kg d.w.
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 71.4 - 143 other: mL/kg d.w.
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 7286-14571 mg as/kg d.w.
- Details on results:
- The test substance was found not to have had a negative effect on the body weight of surviving eatrhworms. There was a statistically significant increase in body weight of the surviving earthworms at the 28.6 mL/ kg d.w. concentration.
- Results with reference substance (positive control):
- No data reported.
- Reported statistics and error estimates:
- No data reported.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 14-day LC50 for earthworms of TEM 123is 71.4-143 mL/kg of dry artificial soil based on nominal concentrations. This converts to 7286-14571 mg as/kg of dry artifical soil.
- Executive summary:
Lang (1995) has been given a Klimisch score of 4 - not assignable (Klimisch et al, 1996) as the study has not been received and therefore has not been properly evaluated. A summary of the study is included in the EU Draft Assessment Report for Acetic Acid (August 2008).
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