Registration Dossier
Registration Dossier
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EC number: 200-580-7 | CAS number: 64-19-7
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: English summary only. Information extracted from acetic acid DAR under Dir 91/414/EEC
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Pathology due to acetic acid: observations on experimental animals and men.
- Author:
- Ghiringhelli L & Di Fabio A
- Year:
- 1 957
- Bibliographic source:
- Med Lavoro, vol 48, pp559-565
Materials and methods
- Study type:
- other: no details reported
- Endpoint addressed:
- skin irritation / corrosion
- eye irritation
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A group of 12 workers emploed for 2-19 years in a cellulose acetate factory were observed for irritative symptoms in skin, eyes and respiratory tract.
- GLP compliance:
- no
Test material
- Reference substance name:
- Acetic acid
- EC Number:
- 200-580-7
- EC Name:
- Acetic acid
- Cas Number:
- 64-19-7
- Molecular formula:
- C2H4O2
- IUPAC Name:
- acetic acid
- Details on test material:
- - Name of test material (as cited in study report): Acetic acid
- Other: No further details reported
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- A group of 12 workers employed for 2-19 years in a cellulose acetate factory were observed for irritative symptoms in skin, eyes and respiratory tract. The average concentration of acetic acid vapour in the air was 0.125 mg/L but could increase to an average of 0.44 mg/L during certain work phases.
Results and discussion
- Results:
- Irritative symptoms of the conjunctiva and upper respiratory tract were observed in 8 individuals.
Erosion of the incisors was noted in 5 workers.
All workers had palmar skin that was dry, thickened and blackened with rhagadiform lesions. (taken from EU DAR acetic acid, 2008).
Applicant's summary and conclusion
- Conclusions:
- Long term exposure to concentrations of acetic acid vapour (average 0.125 mg/L with peaks of up to 0.44 mg/L) was associated with hyperkeratotic dermatitis with rhagdiform lesions of the palmar skin of the hands and respiratory and conjunctival irritation.
- Executive summary:
In a group of 12 workers employed for 2 years of more in a factory where the average concentration of acetic acid vapour was 0.125 mg/L (with peaks of up to 0.44 mg/L during certain work phases), hyperkeratotic dermatitis with rhagdiform lesions of the palmar skin of the hands was present in all workers while respiratory and conjunctival irritation.was present in 8. Five workers also had some erosion on their incisors.
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