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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 August 1984 - 18 September 1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given: study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Principles of method if other than guideline:
Groups of 10 male rats were gavaged with ethyl acrylate as a 0.5 %  aqueous dispersion in Methocel at a constant volume of 10 ml/kg. All rats were fasted overnight prior to dosing and were observed for 14 days following dosing.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl acrylate
EC Number:
205-438-8
EC Name:
Ethyl acrylate
Cas Number:
140-88-5
Molecular formula:
C5H8O2
IUPAC Name:
ethyl acrylate
Details on test material:
- Name of test material (as cited in study report): Ethyl acrylate
- Analytical purity: 99 %
- Lot/batch No.: 070381

Test animals

Species:
rat
Strain:
other: CRCD
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River Kingston
- Fasting period before study: Animals were fasted overnight before gavage

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Methocel
Doses:
Control, 710, 840, 1000, 1190, 1410, 1680, 2000 and 2380 mg/kg bw. Dosing volume 10 ml/kg bw.
No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 120 mg/kg bw
95% CL:
1 010 - 1 240
Mortality:
Deaths generally occurred within 1 day of dosing. 1/10, 1/10, 2/10, 6/10, 8/10, 10/10, 10/10 and 10/10 animals died in the dose groups of 710, 840, 1000, 1190, 1410, 1680, 2000 and 2380 mg/kg bw, respectively. No mortality was observed in the control group.
Clinical signs:
other: Signs of central  nervous system depression (passiveness, ataxia) and/or respiratory depression (cyanosis, abdominal breathing) were observed at lethal doses,  possibly secondary to the severe gastrointestinal irritation evidenced at  necropsy.
Gross pathology:
Necropsy observations in the decedents included stomachs enlarged 2-3 times of normal size, filled with tan fluid. Reddened stomach mucosa and intestines, and thoracic cavity filled with clear or red fluid. No gross changes were observed in the survivors.

Any other information on results incl. tables

Dosage (mg/kg bw)  Mortality Rate
   0             0/10
 710             1/10
 840             1/10
1000             2/10
1190             6/10
1410             8/10
1680             10/10
2000             10/10
2380             10/10

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU