Ethyl acrylate

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1986

Materials and methods

Type of study / information:

Forestomach Lesion Evaluation

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl acrylate

EC Number:

205-438-8

EC Name:

Ethyl acrylate

Cas Number:

140-88-5

Molecular formula:

C5H8O2

IUPAC Name:

ethyl acrylate

Details on test material:

- Name of test material (as cited in study report): Ethyl acrylate
- Analytical purity: no data

Results and discussion

Any other information on results incl. tables

Forestomach weights at EA doses greater than 20 mg/kg bw were increased significantly (214% at 200 mg/kg bw) relative to the vehicle control 24 hr after the last dose. This increase in the ambient weight of the organ was due to inflammation and hyperplasia. The forestomach weight was further increased in the first 6 hr following the last dose (306% of control at the 200 mg/kg bw dose) in an acute inflammatory response of the organ. The ambient NPSH concentration of the forestomach was elevated following EA dosing (reaching 198% of control at the 200 mg/kg bw dose), but was depleted immediately following dosing (reaching 12% of the control value 6 hr after the 200 mg/kg dose). By contrast, the glandular stomach did not demonstrate similar changes in organ weight or NPSH levels in response to EA dosing. Studies conducted with EA in the drinking water at the same total body burden did not result in similar increases in forestomach weight or NPSH content. The results indicate that repeated gavage dosing of EA results in a significant increase in  the detoxification capacity of the forestomach (4-fold at doses of 200 mg/kg bw) that remains insufficient to detoxify bolus EA doses greater than 50 mg/kg bw.