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EC number: 215-236-1 | CAS number: 1314-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 68.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Value:
- 1 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Additional information - workers
- Acute dermal/inhalation systemic DNEL:
According to RIP 3.2.2, Chapter R8, R8.1.2.5, p. 16 no acute DNELs were derived since no acute toxicity hazard has been identified. The acute local DNEL also covers possible acute toxic effects.
- Acute dermal/inhalation local DNEL:
Diphosphorus
pentaoxide is highly corrosive. Dilution with water is very exothermic
and contributes to the corrosive activity of this material. The anion
Phosphate is a naturally occurring dietary and body constituent.
The following DNELs were derived as default values:
-acute dermal exposure: the material is highly corrosive and dermal exposure must be avoided. According to the Dangerous Preparation Directive 1999/45/EC and Regulation 1272/2008/EC a formulation containing < 1% of a corrosive substance (R35, H314) has not to be labeled as corrosive or irritant. Therefore, the dermal acute DNEL for local effects is set at < 1%.
-acute inhalation exposure: the material is highly corrosive and exposure by inhalation must be avoided. According to EU OEL- Directive on indicative exposure limits (revision:07/02/2006) the time-weighted average – 8 hours value is 1 mg/m3.
- DNEL derivation
There is no systemic toxicity but corrosion and irritation at the port of entry expected to occur; the DNEL for local effects protects also from systemic toxicity.
However, in case of a very unlikely systemic exposure long-term systemic DNELs were derived as follows:
Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local effects due to the strong corrosivity of the generated phosphoric acid. Consequently, the toxicity of Phosphoric acid/Diphosphorus pentaoxide, respectively is solely based on secondary effects of corrosivity. Due to the rapid and complete hydrolysis of Diphosphorus pentaoxide the only compound which will be available systemically after exposure is Phosphate.
Phosphate is known to be a food additive and an ADI(Acceptable Daily Intake) value for Phosphorus for the general population based on Phosphate toxicity data is available. According to the FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization) it is set at 30-70 mg Phosphorus/kg bw (FAO Nutrition Meetings, Report Series No. 48A, WHO/FOODADD/70.39 June 1970 and Report Series No. 17, May 1998). In general, the ADI is a very conservative approach and applicable on the general population (incl. children, pregnant women and the elderly population). Therefore, it is justified to use this value instead of a long-term oral DNEL for humans (workers as well as consumers).
Long-term dermal systemic DNEL based
on ADI(Phosphorus; derived by FAO/WHO Expert Commitee):
- DNEL(dermal) derived according to “Guidance on information
requirements and chemical safety assessment”, Chapter R8-2, Example B.5
(p. 69).
corrected DNEL(dermal) =ADI(Phosphorus; oral, human) x
Absorption(oral-human)/Absorption(dermal-human)
= 30 mg/kg bw x
100%/100%
= 30 mg/kg bw
- since this DNEL(Phosphorus; dermal) is derived from an accepted ADI
which includes valid toxicity data as well safety factors, the
application of further assessment factors is not necessary.
=>30 mg Phosphorus/kg bw/d
As above mentioned Diphosphorus pentaoxide is hydrolysed to Phosphoric acid when it comes in contact with water (most common liquid in organisms) according to the following formula:
P2O5+ 3H2O → 2 H3PO4
This means that 2 mol Phosphate will be formed out of 1 mol Diphosphorus Pentaoxide. Diphosphorus Pentaoxide will be completely hydrolysed to Phosphate when dissolved in water. With reference to the chemical parameters mentioned below the
long-term dermal systemic DNEL for Diphosphorus pentaoxide is calculated to be: 68.7 mg/kg bw/d withMolecular weight (P2O5): 142 g/mol
Molecular weight (P-): 31 g/mol
30 mg Phosphorus/31 g/mol = 9.68 x 10-5mol Phosphorus
(9.68 x 10-5mol x 142 g P2O5/mol) / 2 = 68.7 mg/kg bw/d Diphosphorus pentaoxide
Long-term inhalatory DNEL based
on ADI (Phosphorus; derived by FAO/WHO Expert Commitee):
- DNEL(inhalation) derived based on the following assumptions
ADI = 30 mg Phosphorus/kg bw/d
DNEL(P2O5; dermal) = 68.7 mg/kg bw/d
Average body weight = 70 kg (according to “Guidance on information requirements and chemical safety assessment”, Chapter R8.4.3.1, p. 30)
=>acceptable daily systemic dose= 68.7 mg/kg bw/d x 70 kg =4809 mg/d
Respiratory volume (worker, 8h, light activity) = 10 m3/person (according to “Guidance on information requirements and chemical safety assessment”, Chapter R8.4.2, Table R8-2, p. 26)
=>DNEL(inhalation)= 4809 mg / 10 m3=480.9 mg/m3
The calculated DNEL(inhalation) is very unlikely to occur. Working in an atmosphere containing 480.9 mg/m3 Diphosphorus pentaoxide dust is not possible due to the strong corrosive properties of this substance. Therefore, in order to follow the most conservative approach the acute inhalation DNEL for local effects, 1 mg/m3(please refer to DNEL derivation “Acute dermal/inhalation local DNEL”), was chosen as DNEL(inhalation).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 68.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Value:
- 1 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 68.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
- Acute dermal/inhalation systemic DNEL:
According to RIP 3.2.2, Chapter R8, R8.1.2.5, p. 16 no acute DNELs were derived since no acute toxicity hazard has been identified. The acute local DNEL also covers possible acute toxic effects.
- Acute dermal/inhalation local DNEL:
Diphosphorus
pentaoxide is highly corrosive. Dilution with water is very exothermic
and contributes to the corrosive activity of this material. The anion
Phosphate is a naturally occurring dietary and body constituent.
The following DNELs were derived as default values:
-acute dermal exposure: the material is highly corrosive and dermal exposure must be avoided. According to the Dangerous Preparation Directive 1999/45/EC and Regulation 1272/2008/EC a formulation containing < 1% of a corrosive substance (R35, H314) has not to be labelled as corrosive or irritant. Therefore, the dermal acute DNEL for local effects is set at < 1%.
-acute inhalation exposure: the material is highly corrosive and exposure by inhalation must be avoided. According to EU OEL- Directive on indicative exposure limits (revision:07/02/2006) the time-weighted average – 8 hours value is 1 mg/m3.
DNEL derivation
There is no systemic toxicity but corrosion and irritation at the port of entry expected to occur; the DNEL for local effects protects also from systemic toxicity.
However, in case of a very unlikely systemic exposure long-term systemic DNELs were derived as follows:
Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local effects due to the strong corrosivity of the generated phosphoric acid. Consequently, the toxicity of Phosphoric acid/Diphosphorus pentaoxide, respectively is solely based on secondary effects of corrosivity. Due to the rapid and complete hydrolysis of Diphosphorus pentaoxide the only compound which will be available systemically after exposure is Phosphate.
Phosphate is known to be a food additive and an ADI(Acceptable Daily Intake) value for Phosphorus for the general population based on Phosphate toxicity data is available. According to the FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization) it is set at 30-70 mg Phosphorus/kg bw (FAO Nutrition Meetings, Report Series No. 48A, WHO/FOODADD/70.39 June 1970 and Report Series No. 17, May 1998). In general, the ADI is a very conservative approach and applicable on the general population (incl. children, pregnant women and the elderly population). Therefore, it is justified to use this value instead of a long-term oral DNEL for humans (workers as well as consumers).
Long-term oral/ dermal systemic DNEL based
on ADI(Phosphorus; derived by FAO/WHO Expert Commitee):
- DNEL(dermal) derived according to “Guidance on information
requirements and chemical safety assessment”, Chapter R8-2, Example B.5
(p. 69).
corrected DNEL(dermal) =ADI(Phosphorus; oral, human) x
Absorption(oral
-human)/Absorption(dermal-human)
= 30 mg/kg bw x
100%/100%
= 30 mg/kg bw
- since this DNEL(Phosphorus; dermal) is derived from an accepted ADI
which includes valid toxicity data as well safety factors, the
application of further assessment factors is not necessary.
=>30 mg Phosphorus/kg bw/d
As above mentioned Diphosphorus pentaoxide is hydrolysed to Phosphoric acid when it comes in contact with water (most common liquid in organisms) according to the following formula:
P2O5+ 3H2O → 2 H3PO4
This means that 2 mol Phosphate will be formed out of 1 mol Diphosphorus Pentaoxide. Diphosphorus Pentaoxide will be completely hydrolysed to Phosphate when dissolved in water. With reference to the chemical parameters mentioned below the
long-term oral/dermal systemic DNEL for Diphosphorus pentaoxide is calculated to be: 68.7 mg/kg bw/d
Long-term inhalatory DNEL based on
ADI(Phosphorus; derived by FAO/WHO Expert Commitee):
- DNEL(inhalation) derived based on the following assumptions
ADI = 30 mg Phosphorus/kg bw/d
DNEL(P2O5; dermal) = 68.7 mg/kg bw/d
Average body weight = 70 kg (according to “Guidance on information requirements and chemical safety assessment”, Chapter R8.4.3.1, p. 30)
=>acceptable daily systemic dose= 68.7 mg/kg bw/d x 70 kg = 4809 mg/d
Respiratory volume (24h) = 20 m3/person (according to “Guidance on information requirements and chemical safety assessment”, Chapter R8.4.2, Table R8-2, p. 26)
=>DNEL(inhalation)= 4809 mg / 20 m3= 240.5 mg/m3
The calculated DNEL(inhalation) is very unlikely to occur. The stay in an atmosphere containing 240.5 mg/m3Diphosphorus pentaoxide dust is not possible due to the strong corrosive properties of this substance. Therefore, in order to follow the most conservative approach the acute inhalation DNEL for local effects, 1 mg/m3(please refer to DNEL derivation “Acute dermal/inhalation local DNEL”), was chosen as DNEL(inhalation).
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