Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-715-9 | CAS number: 12607-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
General Information
- Name:
- Nickel Hydroxycarbonate
- Implementation:
- EU
- Type of classification:
- harmonised classification
- Remarks:
- Ni hydroxycarbonate currently carries a minimum harmonized classification of Acute Tox 4;H332 for acute inhalation toxicity in the EU. Section 1.2.1 of the CLP Regulations states that a minimum classification "shall be applied if none of the following conditions are fulfilled:...the manufacturer or importer has access to data or other information as specified in Part 1 of Annex I that lead to classification in a more severe category compared to the minimum classification. Classification in the more severe category must then be applied". The findings of a recently completed OECD-guideline compliant study suggest that a gender-specific effect may be causing increased toxicity in males as compared to females. Although the LC50 in females was greater than the highest dose tested (2.09 mg/L), the LC50 of 0.24 mg/L in males should be carried forward as a conservative approach to classification. This indicates that a more stringent classification of Acute Tox. 2:H330 is warranted. In accordance with the rules set by the CLP Regulation, the minimum harmonized classification has been changed to Acute Tox. 2:H330 for this registration file and CSR. A complete summary of the testing program including results and discussion are provided in Section 7.2.2 of IUCLID.
- Ni hydroxycarbonate has a harmonized classification of Skin Irrit. 2; H315 according to the 1st ATP to the CLP. However, the results of a recently completed guideline-based, GLP study do not meet the classification criteria for this endpoint. While no change to the existing classification is proposed within this registration file, a complete summary of the testing program including results and discussion are provided in Section 7.3.1 of IUCLID and Section 5.3 of the CSR.
- Ni hydroxycarbonate is not currently classified for eye irritation according to the 1st ATP to the CLP Regulation. However, a review of the updated CLP classfication criteria resulted in the determination of self-classification of Ni hydroxycarbonate as an eye irritant (Eye Irrit. 2; H319). Therefore, this registration file reflects eye irritation as a self-classification. A complete summary of the testing program including results and discussion are provided in Section 7.3.2 of IUCLID and Section 5.3.2 in the accompanying CSR.
- Ni hydroxycarbonate has a harmonized classification as a dermal sensitizer (Skin Sens. 1; H317) according to the 1st ATP to the CLP Regulation. However, the results of a comprehensive bioaccessibility testing program evaluating release of Ni ion in synthetic sweat from various Ni compounds indicate that Ni hydroxycarbonate releases less nickel (II) ion compared to water soluble nickel substances known to be skin sensitizers (including nickel sulphate and nickel chloride), but releases similar amounts of nickel ion to nickel metal, which is also a known skin sensitizer. This suggests that nickel hydroxycarbonate is probably a skin sensitizer but with lesser potency than water soluble nickel compounds like nickel sulphate. Although the bioaccessibility method has not yet been validated in vivo, the classification for skin sensitization for nickel hydroxycarbonate is appropriate to be read-across from nickel sulphate or nickel since both are skin sensitizers. An explanation of the rationale and methodology is provided in Section 7.4.1 of IUCLID and as Appendix B3 of the CSR.
- In the Labelling section, the hazard pictogram GHS06 (skull and crossbones), associated with the change in Acute Inhalation Toxicity classification, overrides the hazard pictogram GHS07 (exclamation mark) according to the Guidance on Labelling and Packaging in accordance with Regulation (EC) No 1272/2008. Therefore, in accordance with the CLP, the hazard pictogram GHS07 is not included in the IUCLID file or this Chemical Safety Report.
- Please note that the REACH registration for nickel hydroxycarbonate (CAS # 12607-70-4) does not include nickel carbonate (CAS # 3333-67-3), as it is neither manufactured nor imported since large-scale production of pure nickel carbonate is not viable. See CSR Appendix E1 for additional information.
Related composition
- Related composition:
- Nickel hydroxycarbonate (CAS # 12607-70-4
- Nickel hydroxycarbonate (CAS # 12122-15-5)
Classificationopen allclose all
Explosives
- Reason for no classification:
- data conclusive but not sufficient for classification
Flammable gases and chemically unstable gases
- Reason for no classification:
- data conclusive but not sufficient for classification
Aerosols
- Reason for no classification:
- data conclusive but not sufficient for classification
Oxidising gases
- Reason for no classification:
- data conclusive but not sufficient for classification
Gases under pressure
- Reason for no classification:
- data conclusive but not sufficient for classification
Flammable liquids
- Reason for no classification:
- data conclusive but not sufficient for classification
Flammable solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Self-reactive substances and mixtures
- Reason for no classification:
- data conclusive but not sufficient for classification
Pyrophoric liquids
- Reason for no classification:
- data conclusive but not sufficient for classification
Pyrophoric solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Self-heating substances and mixtures
- Reason for no classification:
- data conclusive but not sufficient for classification
Substances and mixtures which in contact with water emit flammable gases
- Reason for no classification:
- data conclusive but not sufficient for classification
Oxidising liquids
- Reason for no classification:
- data conclusive but not sufficient for classification
Oxidising solids
- Reason for no classification:
- data conclusive but not sufficient for classification
Organic peroxides
- Reason for no classification:
- data conclusive but not sufficient for classification
Corrosive to metals
- Reason for no classification:
- data lacking
Desensitized explosives
- Reason for no classification:
- data lacking
Acute toxicity - oral
- Hazard category:
- Acute Tox. 4
- Hazard statement:
- H302: Harmful if swallowed.
Acute toxicity - dermal
- Reason for no classification:
- data conclusive but not sufficient for classification
Acute toxicity - inhalation
- Hazard category:
- Acute Tox. 2
- Hazard statement:
- H330: Fatal if inhaled.
Skin corrosion / irritation
- Hazard category:
- Skin Irrit. 2
- Hazard statement:
- H315: Causes skin irritation.
Serious eye damage / eye irritation
- Hazard category:
- Eye Irrit. 2
- Hazard statement:
- H319: Causes serious eye irritation.
Respiratory sensitisation
- Hazard category:
- Resp. Sens. 1
- Hazard statement:
- H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Skin sensitisation
- Hazard category:
- Skin Sens. 1
- Hazard statement:
- H317: May cause an allergic skin reaction.
Aspiration hazard
- Reason for no classification:
- data lacking
Reproductive toxicity
- Hazard category:
- Repr. 1B
- Hazard statement:
- H360D: May damage the unborn child.
- Specific effect:
- Perinatal mortality
Effects on or via lactation
- Reason for no classification:
- data conclusive but not sufficient for classification
Germ cell mutagenicity
- Hazard category:
- Muta. 2
- Hazard statement:
- H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Carcinogenicity
- Hazard category:
- Carc. 1A
- Hazard statement:
- H350i: May cause cancer by inhalation.
- Route of exposure:
- inhalation
1. Specific target organ toxicity - single (STOT-SE)
- Reason for no classification:
- data conclusive but not sufficient for classification
1. Specific target organ toxicity - repeated (STOT-RE)
- Hazard category:
- STOT Rep. Exp. 1
- Hazard statement:
- H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Affected organs:
- lungs
- Route of exposure:
- inhalation
Hazardous to the aquatic environment (acute / short-term)
- Hazard category:
- Aquatic Acute 1
- Hazard statement:
- H400: Very toxic to aquatic life.
Hazardous to the aquatic environment (long-term)
- Hazard category:
- Aquatic Chronic 1
- Hazard statement:
- H410: Very toxic to aquatic life with long lasting effects.
- M-Factor acute:
- 1
- M-Factor chronic:
- 1
Hazardous to the ozone layer
- Reason for no classification:
- data conclusive but not sufficient for classification
Labelling
- Signal word:
- Danger
Hazard pictogram
- GHS06: skull and crossbones
- GHS08: health hazard
- GHS09: environment
Hazard statements
- H350i: May cause cancer by inhalation.
- H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- H360D: May damage the unborn child.
- Perinatal mortality
- H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Affected organ: Lungs; Route of exposure: Inhalation
- H330: Fatal if inhaled.
- H302: Harmful if swallowed.
- H315: Causes skin irritation.
- H319: Causes serious eye irritation.
- H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H317: May cause an allergic skin reaction.
- H410: Very toxic to aquatic life with long lasting effects.
Notes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.