Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-650-8 | CAS number: 123-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 15 through April 29, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: It was noted that the study report lacked a number of important details (specifically regarding the test material, such as the expiry date), however the study was conducted in accordance with EC and OECD test guidelines, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- C,C'-azodi(formamide)
- EC Number:
- 204-650-8
- EC Name:
- C,C'-azodi(formamide)
- Cas Number:
- 123-77-3
- Molecular formula:
- C2H4N4O2
- IUPAC Name:
- diazene-1,2-dicarboxamide
- Details on test material:
- - Name of test material (as cited in study report): Unifoam AZ SO-NL
- Substance type: yellow powder
- Physical state: solid
- Analytical purity: 100%
- Impurities (identity and concentrations): none reported
- Lot/batch No.: Not reported.
- Expiration date of the lot/batch: Not reported.
- Stability under test conditions: Not reported.
- Storage condition of test material: Ambient temperature, in the dark.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K. Limted, Margate, Kent, England
- Age at study initiation: four to six weeks
- Weight at study initiation: 113 to 146 gram
- Fasting period before study: overnight prior to thru 4 hours after dosing
- Housing: in groups, by sex, in metal cages with wire mesh floors
- Diet (e.g. ad libitum): standard rodent diet (Labsure LAD1) ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: nine days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 to 23 °C
- Humidity (%): 57%
- Air changes (per hr): 15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% w/v concentration
MAXIMUM DOSE VOLUME APPLIED: 20.0 ml/kg - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 Days
- Frequency of observations and weighing:Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1 (a period of five hours). On subsequent days the animals were observed once in the morning and again at the end of the experimental day. This latter observation was at approximately 16.30 hours on week days or 11.30 hours on Saturday and Sunday. Clinical signs were recorded at each observation.
- Necropsy of survivors performed: yes
- Other examinations performed: All animals on the main study were killed on Day 15 by cervical dislocation and were subjected to a macroscopic post mortem examination which consisted of opening the abdominal and thoracic cavities. The macroscopic appearance of abnormal organs when present was recorded.
Results and discussion
- Preliminary study:
- Results of the preliminary study indicated that the acute lethal oral dose of Unifoam AZ SO-NL was greater that 5.0 g/kg bodyweight. One group of ten rats (five males and five females) was dosed at 5.0 g/kg to confirm the result of the preliminary study.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: Pilo-erection and abnormal body carriage (hunched posture) were observed in all rats within five minutes of dosing. Pilo-erection alone persisted throughout the remainder of Day 1. There were no other clinical signs and recovery, as judged by external a
- Gross pathology:
- Terminal autopsy findings were normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal oral dose to rats of Unifoam AZ SO-NL was found to be greater than 5.0 g/kg bodyweight.
- Executive summary:
An acute oral toxicity test was performed to determine the acute toxicity by oral exposure of the test substance AZ SO-NL. The study was conducted in accordance with relevant EC and OECD test guidelines, and in compliance with GLP (HLS 1988, 88720D/OCI 64/AC).
A group of ten rats (five male and five female) were dosed with 5000 mg test substance/kg bodyweight by oral gavage, then observation for mortality and clinical signs performed over a period of 14 days. At the end of the observation period, all animals were sacrificed and postmortem examinations performed.
No deaths occured in the test rats. Piloerection and hunched posture were seen in all rats within five minutes of dosing, and piloerection persisted for the remainder of the day of dosing; all animals had recovered by day 2 and no further unusual clinical signs were seen. Slightly low bodyweight gains were recorded for two male and one female rat, however all other rats made the anticipated weight gains. Terminal autopsy findings were normal.
The acute lethal oral dose to rats of Unifoam AZ SO-NL was found to be greater than 5.0 g/kg bodyweight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.