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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not available. Documentation insufficient for assessment. Treatment period (9 days) insufficient and not in accordance with current test guidelines

Data source

Reference
Title:
No information
Author:
EPA
Year:
1988
Bibliographic source:
Document No. 86-8870000331, Microfiche No. OTS0516482
Report Date:
1988

Materials and methods

Principles of method if other than guideline:
Method: other: according to TSCA and EPA guidelines
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Purity >99.5%

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
9 days
Frequency of treatment:
5 days treatment, 2 days no treatment, 4 days treatment
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 0.5, 1.0 ml/kg/day (= 0, 417, 834 mg/kg bw/day)
Basis:

No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
Post-exposure period: none

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

There were no treatment-related effects on clinical signs of
toxicity, food consumption, or body weight following
cutaneous exposure to 2-ethylhexanol. Lymphopenia and decreased spleen weight for high dose females and increased
triglycerides for females at both dose levels compared to
controls were observed. No other treatment-related effects
on clinical pathology measurements or organ weights were
observed for males or females at either dose level.
Treatment-related anatomic and histologic lesions observed
following cutaneous exposure to 2-ethylhexanol were
restricted to the site of application and included
exfoliation, acanthosis, hyperkeratosis, eschar formation,
dermatitis and edema.

Applicant's summary and conclusion

Conclusions:
Not Assignable. Original reference not yet available. Documentation insufficient for assessment.
Treatment period (9 days) insufficient and not in accordance with current test guidelines.

Reportedly, there were local skin reactions but no systemic toxicity noted following repeated dermal application (9 days).